GAP-26

Name	GAP 26
Synonyms	VR-13 GAP26 GAP 26 GAP-26 GAP26 43Gap 26, Connexin Mimetic M.W. 1550.78 C70H107N19O19S Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg H-VAL-CYS-TYR-ASP-LYS-SER-PHE-PRO-ILE-SER-HIS-VAL-ARG-OH L-Arginine, L-valyl-L-cysteinyl-L-tyrosyl-L-α-aspartyl-L-lysyl-L-seryl-L-phenylalanyl-L-prolyl-L-isoleucyl-L-seryl-L-histidyl-L-valyl-
CAS	197250-15-0

Molecular Formula	C70H107N19O19S
Molar Mass	1550.78
Density	1.47±0.1 g/cm3(Predicted)
Water Solubility	Soluble to 2 mg/ml in water
Solubility	H2O : 50 mg/mL (32.24 mM; Need ultrasonic)
pKa	3.31±0.10(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,2-8°C
Use	Gap 26 is a connexin (connexin) mimetic peptide consisting of residues 63-75 of the first extracellular loop of connexin connexin 43 (gap junction blocker) and containing the SHVR amino acid motif.
In vitro study	Gap 26 (0.25 mg/mL, 30 min) reduces the wave size in the three cell lines (RBE4, SV-ARBEC and ECV304). Gap 26 (0.25 mg/mL, 30 min) completely abolishes the InsP3-triggered ATP response and reduced the ATP release to below the control level, indicating that the basal ATP release is also affected. Gap 26 does indeed significantly inhibit our InsP3-triggered intercellular calcium waves, but it did not have any effect on dye coupling through junctional channels as evidenced by the FRAP experiments, despite the fact that connexin 43 was present in the cell lines used. Gap 26 (100-300 μM) dose-dependently reduces the rhythmic responses of rabbit superior mesenteric arteries, with IC 50 of 28.4 ± 3.4 μM.

Last Update：2024-01-02 23:10:35

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