GARDOL
sodium N-lauroylsarcosinate
CAS: 137-16-6;7631-98-3
Molecular Formula: C15H28NO3.Na
GARDOL - Names and Identifiers
GARDOL - Physico-chemical Properties
| Molecular Formula | C15H28NO3.Na |
| Molar Mass | 293.38 |
| Density | 1.033g/mLat 20°C |
| Melting Point | 46 °C |
| Flash Point | 267℃ |
| Water Solubility | Soluble in water (293 g/L). |
| Solubility | It's hygroscopic. Soluble in aqueous alcohol solutions such as water, ethanol or glycerol. |
| Vapor Presure | 0.02 hPa (20 °C) |
| Appearance | White powder |
| Specific Gravity | 1.03 (20/4℃) |
| Color | White |
| Maximum wavelength(λmax) | ['λ: 260 nm Amax: 0.2', , 'λ: 280 nm Amax: 0.06'] |
| Merck | 14,4368 |
| BRN | 5322974 |
| PH | 7.0-9.0 (25℃, 1M in H2O) |
| Storage Condition | room temp |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Sensitive | Hygroscopic |
| MDL | MFCD00042728 |
| Use | It is an anionic surfactant, especially suitable for the preparation of shampoo, Bath, facial cleanser, baby detergent, dishwashing detergent, etc. |
GARDOL - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R41 - Risk of serious damage to eyes R38 - Irritating to the skin R23 - Toxic by inhalation |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S27 - Take off immediately all contaminated clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S38 - In case of insufficient ventilation, wear suitable respiratory equipment. S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | UN 2811 6.1 / PGII |
| WGK Germany | 3 |
| RTECS | MC0598960 |
| FLUKA BRAND F CODES | 3-10 |
| TSCA | Yes |
| HS Code | 34021190 |
| Hazard Class | 6.1 |
| Packing Group | II |
| Toxicity | LD50 orally in Rabbit: 2888 mg/kg |
GARDOL - Upstream Downstream Industry
| Raw Materials | Phosphorus trichloride Lauric acid |
GARDOL - Introduction
This product is a powdery mild, biodegradable amino acid anionic surfactant.
Last Update：2022-10-16 17:13:39
GARDOL - Reference Information
| LogP | 0.37 |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| introduction | sodium lauryl sarcosine, English name is SODIUM LAUROYL SARCOSINATE, alias: sodium lauryl-N-methylaminoacetate, sodium dodecyl-N-methylglycine. Sodium lauryl sarcosine is mainly used in cosmetics and skin care products as antistatic, foaming agent, detergent and surfactant. The risk coefficient is 3. It is relatively safe and can be used with confidence. It generally has no effect on pregnant women. Sodium lauryl sarcosine has no acne-causing properties. FDA approves sodium lauryl sarcosine as a direct food additive, and CIR allows it to be used in rinse products and resident products at concentrations not exceeding 5%. |
| Effect | Sodium lauryl sarcosine is a foaming agent and surfactant, it is lauryl sarcosine salt (made from creatine or caffeine decomposition), a modified fatty acid. It is often used as a foaming agent, surfactant and hair conditioner in shampoo, shower gel, facial cleanser and shaving products. |
| application | sodium N-laurophthalein myosinate is an anionic amino acid surfactant with low toxicity, low irritation, good biodegradability, better compatibility, antibacterial and corrosion resistance, etc, widely used in daily chemicals, food, metal processing, mineral flotation, pesticide deployment, biomedicine and many other fields |
| safety | sodium lauryl sarcosine can be found in the cosmetics database as a moderately dangerous ingredient, mainly because it may contain impurity nitrosamines (nitrosamine, a well-known carcinogen), and because it is considered as a penetration aid, it can change the skin structure and help other chemicals penetrate deep into the skin. CosmeticsInfo.org believes that sodium lauryl sarcosine should not be used in cosmetics and personal care products because it may form nitroso (N-nitroso) compounds. Sodium lauryl sarcosine does not have the potential toxicity and harm expected, and it is orally low-toxic. It was not found to be mutated, irritating or allergenic. However, as mentioned earlier, it can promote other ingredients to penetrate the skin. |
| synthesis method | 1) synthesis of lauroyl chloride: add a certain amount of lauric acid into a dry three-mouth flask equipped with a reflux condenser, heat and melt, control the temperature at 60 ~ 70e, slowly add phosphorus trichloride dropwise under full stirring, react for 2 hours, let stand for stratification, remove the phosphorous acid in the lower layer, and obtain the upper layer of lauroyl chloride. 2) Synthesis of N-lauroyl sarcosine: Add a certain amount of sodium sarcosinate solution and solvent tetrahydrofuran to a four-mouth flask with an electric stirrer and a reflux condenser, and add lauroyl chloride and sodium hydroxide aqueous solution dropwise under stirring. The pH value of the reaction system is controlled within the range of 9~11. After the dropwise addition is completed, continue to react for 3 hours to recover the solvent, use dilute acid to adjust the pH value to 1~2 to convert sodium N-lauryl sarcosine into water-insoluble N-lauryl sarcosine, thereby separating from water-soluble inorganic salt impurities. Use ether to extract the product, wash the upper oil layer to neutral, dry anhydrous sodium sulfate, evaporate the solvent, and recrystallize with petroleum ether to obtain white needle-like crystals. |
| use | sodium dodecyl sarcosine is an amino acid surfactant. in addition to excellent surface activity, it also has the characteristics of antibacterial, bactericidal, corrosion and rust inhibition, and good biodegradability. therefore, it is widely used in many fields such as detergents, cosmetics, food and beverages, metal rust prevention, mineral flotation, pesticides and biomedicine. Biochemical research. Anionic surfactant. Hexokinase inhibitors. Anionic detergent. Isolation of yeast ribonucleic acid. It can be used for RNA and DNA segregation, as a dissolving agent in cell purification, an additive when separating DNA from human serum, and can also increase the nitrogen fixation ability of legume rhizobia by adding this product. There are also many applications in immunochemistry An anionic surfactant. Since it does not produce excessive foam, it can be used for cell lysis in RNA extraction schemes. Relevant scholars have established an analytical method for the determination of sodium dodecyl sarcosinate by gas chromatography. Using dodecyl acid as internal standard, the sample reacts with boron trifluoride methanol solution to generate methyl ester compound, HP-5 chromatographic column is used as analytical column, FID is used as detector, and the internal standard method is used for quantification. |
| Production method | The sarcosine aqueous solution plus sodium hydroxide is prepared by reacting with lauroyl chloride under alkaline conditions. |
Last Update：2024-04-09 20:45:29
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Raw Materials for GARDOL