GDC0994
GDC-0994
CAS: 1453848-26-4
Molecular Formula: C21H18ClFN6O2
GDC0994 - Names and Identifiers
GDC0994 - Physico-chemical Properties
| Molecular Formula | C21H18ClFN6O2 |
| Molar Mass | 440.86 |
| Density | 1.45±0.1 g/cm3(Predicted) |
| Boling Point | 734.6±70.0 °C(Predicted) |
| Solubility | DMSO: ≥ 35 mg/mL |
| pKa | 14.03±0.10(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | GDC-0994 effective inhibition of p90RSK in tumor cells. |
| In vivo study | GDC-0994 (oral) elicited significant multiple single dose activity in in vitro cancer models, including mice with KRAS mutant and BRAF mutant human xenograft tumors. In vivo, GDC-0994 (orally) inhibits ERK phosphorylation and activation of ERK-mediated signal transduction pathways, subsequently preventing ERK-dependent tumor cell proliferation and survival. |
GDC0994 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.268 ml | 11.342 ml | 22.683 ml |
| 5 mM | 0.454 ml | 2.268 ml | 4.537 ml |
| 10 mM | 0.227 ml | 1.134 ml | 2.268 ml |
| 5 mM | 0.045 ml | 0.227 ml | 0.454 ml |
Last Update：2024-01-02 23:10:35
GDC0994 - Introduction
GDC-0994 is a chemical substance that is an inhibitor of a specific tyrosine kinase (TK), which can be used to inhibit the TK signaling pathway and inhibit the growth and spread of tumor cells.
GDC-0994 has good pharmacological properties and can be administered by oral and other routes. It can bind to the target protein in vivo, inhibit its enzyme activity, thereby blocking the related biological signal transduction pathway.
The main application field of this compound is the field of tumor treatment, especially for cancer cells with abnormal activation of TK. It can be widely used in cancer-related clinical research and treatment.
Regarding the preparation method, the preparation method of GDC-0994 is an organic synthesis route. Specific steps include organic synthesis reaction, Structure Identification and purification.
When using GDC-0994, you need to pay attention to its safety. It may have some side effects and toxicity, so it needs to be used under close monitoring. During use, please follow the relevant safety practices and follow the correct dosage and medication regimen according to clinical guidelines.
It is important to emphasize that if you need to use GDC-0994, please do so under the guidance of a professional. Please read the product manual carefully and obtain sufficient safety information before use.
GDC-0994 has good pharmacological properties and can be administered by oral and other routes. It can bind to the target protein in vivo, inhibit its enzyme activity, thereby blocking the related biological signal transduction pathway.
The main application field of this compound is the field of tumor treatment, especially for cancer cells with abnormal activation of TK. It can be widely used in cancer-related clinical research and treatment.
Regarding the preparation method, the preparation method of GDC-0994 is an organic synthesis route. Specific steps include organic synthesis reaction, Structure Identification and purification.
When using GDC-0994, you need to pay attention to its safety. It may have some side effects and toxicity, so it needs to be used under close monitoring. During use, please follow the relevant safety practices and follow the correct dosage and medication regimen according to clinical guidelines.
It is important to emphasize that if you need to use GDC-0994, please do so under the guidance of a professional. Please read the product manual carefully and obtain sufficient safety information before use.
Last Update：2024-04-09 22:01:09
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Spot supply
Product Name: GDC-0994 Visit Supplier Webpage Request for quotationCAS: 1453848-26-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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