GDP
GDP
CAS: 146-91-8
Molecular Formula: C10H15N5O11P2
GDP - Names and Identifiers
| Name | GDP |
| Synonyms | GDP 5'-GDP Guo-5'-P2 5'-GUANYLATEDIPHOSPHATE Guanosine5'-pyrophosphate 5'-guanylatediphosphate(GDP) Guanosine5''-diphosphoricacid Guanosine-5'-diphosphatedisodiumsalt(GDP) [[5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxyphosphonicacid |
| CAS | 146-91-8 |
| EINECS | 231-026-2 |
GDP - Physico-chemical Properties
| Molecular Formula | C10H15N5O11P2 |
| Molar Mass | 443.2 |
| Density | 2.63±0.1 g/cm3(Predicted) |
| Storage Condition | -20℃ |
| Physical and Chemical Properties | Bioactive Guanosine5 '-diphosphate is a nucleoside diphosphate. Guanosine5 '-diphosphate is a potential iron mobilization agent that blocks heptin-iron transporter interactions and modulates the interleukin-6 (IL-6)/stat-3 pathway. |
GDP - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
GDP - Crystallization method of 5 '-guanosine-disodium phosphate salt
from Baidu library
Application (Patent) No.:
CN 201010210408
public/announcement number:
CN101863943 B
Applicant (patentee):
Dalian Zhenao Biotechnology Co., Ltd
Inventor:
Chen Yusong , Chen Yuping , Sun Mingxian , wei li
Summary:
The present invention discloses a crystallization method for 5 '-guanosine-phosphate disodium salt with simple operation, large product crystallization, good fluidity, uniform particles, beautiful color and high purity. Sodium hydroxide is added to 5'-GMP aqueous solution with a concentration of 5%-40%, and the pH value of the solution is adjusted to 7-11, and then anhydrous ethanol and catalyst with a volume of 0.5-3 times of the PH7 -11 solution, stir at a temperature of 15-80 ℃ to precipitate 5 '-GMP and 2Na, centrifuge, wash and dry to obtain 5'-GMP and 2Na crystals; The catalyst is a mixture of 5 '-guanosine-disodium phosphate crystal 60-120 mesh under sieve and sodium carbonate, and the mass ratio of 5'-guanosine-disodium phosphate crystal 60-120 mesh under sieve and sodium carbonate is 1:2, the amount of catalyst added is 1 ~ 2‰ of 5 '-GMP mass.
Last Update：2024-01-02 23:10:35
GDP - Crystallization method of 5 '-guanosine monophosphate disodium
from Baidu library
Application (Patent) No.:
CN200910192082.3
date of application:
September 4, 2009
public/announcement number:
CN101654469
Applicant (patentee):
South China University of Technology; Guangdong Zhaoqing Xinghu Biotechnology Co., Ltd
Inventor:
Jiang yanbin ,< a href = "https://xueshu.baidu.com/s?wd=author: (Li luan) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Li luan ,< a href = "https://xueshu.baidu.com/s?wd=author: (Zheng Mingying) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Zheng Mingying , Zhu Yifu , Rao Hansheng
national and provincial code:
Guangdong
Summary:
P> The invention discloses a crystallization method of 5 '-guanosine monophosphate disodium. The method of the present invention adds sodium salt equivalent to 0.2-2 times of 5 '-guanosine-disodium phosphate and anti-solvent 0.3-3 times the volume of 5'-guanosine-disodium phosphate aqueous solution with a mass fraction of 5%-20% concentration, the crystallization temperature is controlled at 10-60 ℃, the stirring speed is controlled at 50-300r /min, the crystallization is completed, filtration and drying are carried out, 5 '-guanosine monophosphate disodium crystal. Using the method of the present invention, the product quality of the 5 '-guanosine monophosphate disodium crystals obtained reaches the national standard, and the 5'-guanosine monophosphate disodium crystals with stable crystal particle size range can be obtained by controlling the crystallization process conditions and flow field state, with simple operation and good repeatability, relatively short crystallization time, suitable for the industrial production of 5 '-guanosine monophosphate disodium products.Sovereignty Item:
1. A crystallization method of 5 '-guanosine monophosphate disodium, characterized in that it comprises the following steps: (1) Dissolve the crude 5'-guanosine monophosphate disodium in water to prepare a solution of 5-20wt%, carry out decolorization and impurity removal treatment, filtration, and collect filtrate; (2) Add the sodium salt of 5 '-guanosine monophosphate crude disodium 0.2~2 times by weight into the above filtrate, and adjust the pH value to 8.5~10.5; (3) under the condition of rapid stirring, inject an anti-solvent with 0.3-3 times the volume of the filtrate and heat it to 50-60 ℃; keep the temperature and stir; (4) control the stirring rate of the solution obtained in step (3) to be 50-300r /min, and cool down, the temperature is reduced from 50~60 ℃ to 10 ℃ to obtain crystal slurry; (5) filter the crystal slurry, and after washing and drying the filtered crystals, 5'-guanosine monophosphate disodium crystal body is obtained.
Last Update：2023-08-16 22:23:51
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Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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