GENISTIN
genistin
CAS: 529-59-9
Molecular Formula: C21H20O10
GENISTIN - Names and Identifiers
| Name | genistin |
| Synonyms | GENISTIN genistin GLUCOSYL-7-GENISTEIN GENISTEIN-7-GLUCOSIDE Genistein-7-O-glucoside GENISTEIN-7-O-GLUCOSIDE genistin from glycine max 7-O-BETA-D-GLUCOPYRANOSIDE 7-O-B-D-GLUCOPRYANOSYL GENISTEIN GENISTEIN, 7-O-BETA-D-GLUCOPYRANOSIDE 4',5,7-TRIHYDROXYISOFLAVONE 7-GLUCOSIDE 5-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl hexopyranoside 5-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside |
| CAS | 529-59-9 |
| EINECS | 610-921-5 |
| InChI | InChI=1/C21H20O10/c22-7-15-18(26)19(27)20(28)21(31-15)30-11-5-13(24)16-14(6-11)29-8-12(17(16)25)9-1-3-10(23)4-2-9/h1-6,8,15,18-24,26-28H,7H2 |
| InChIKey | ZCOLJUOHXJRHDI-CMWLGVBASA-N |
GENISTIN - Physico-chemical Properties
| Molecular Formula | C21H20O10 |
| Molar Mass | 432.38 |
| Density | 1.642±0.06 g/cm3(Predicted) |
| Melting Point | 254°C |
| Boling Point | 256 °C |
| Specific Rotation(α) | D21 -28° (c = 0.6 in 0.02N NaOH); D26 -21.4° (pyridine) |
| Flash Point | 280.7°C |
| Solubility | Insoluble in water, slightly soluble in hot water, soluble in dimethyl sulfoxide. |
| Vapor Presure | 3.14E-26mmHg at 25°C |
| Appearance | Yellow needle crystal (ethanol) |
| Color | Off-white |
| Merck | 13,4402 |
| BRN | 64479 |
| pKa | 6.12±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week. |
| Refractive Index | 1.717 |
| MDL | MFCD00016883 |
| Physical and Chemical Properties | Insoluble in water, slightly soluble in hot water, soluble in dimethyl sulfoxide derived from legume soybean Glycine max(L.)merr seeds. |
GENISTIN - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | DJ3093000 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 29389090 |
GENISTIN - Reference Information
| Plant source: | Soybean |
| overview | genistein (Genistin) is one of the effective ingredients in soybean isoflavones and is the 7-glucoside of genistein, the effective ingredient in soybean isoflavones. Genin is used for reverse control of high-fractiine and other tyrosine kinase inhibitors. It has the ability to improve insulin resistance, anti-diabetic effect, inhibit cancer cell activity, inhibit prostate cancer and antioxidant activity. Their extraction provides new raw materials and functional additives for the food industry and pharmaceutical industry. |
| soybean extract | soybean extract is also called soybean isoflavone, and the commodity specifications are usually soybean isoflavone 10%, 20% and 40%, etc. Soybean is the seed of leguminous plants. The rich isoflavones in soybean are natural phytoestrogens, which can reduce the incidence of breast cancer in women, relieve menopausal symptoms and increase bone density. Therefore, soybean isoflavones have become a research hotspot in recent years. [crude drug resources] there are 52 countries and regions growing soybeans in the world, with China, the United States, Brazil and Argentina as major soybean exporters. In 1994, the output of soybeans in the United States was 6063 tons, ranking first in the world, Brazil 2468 tons, and China 1640 tons, ranking second and third respectively. [crude drug ingredients] isoflavones mainly include daidzein (Daidzein, 1), genistein (Genistein, 2), daidzein (Glycitein, 3), and glucoside, acetyl glucoside, malonyl glucoside, glucoside are daidzein (Daidzin, 4), genistein (Genistin, 5), daidzein (Glycitin, 6), etc, malonyl glucoside is 6 "-O-Malonyldaidzin (7), 6"-O-Malonylgenistin (8), 6 "-O-Malonylglyc-itin (9), acetyl glucoside is 6"-O-Acetyldaidzin(10), 6 "-O-Acctylgenistin(11), 6"-O-Acctylglycitin(12), respectively. The contents of isoflavones in various soybeans are 1200~4216 μg/g, mainly glucoside and malonyl glucoside, with contents of 207~1698 μg/g and 999~2518 μg/g respectively. Fig. 1 shows soybean |
| physical and chemical properties | light yellow needle-like crystals (recrystallized from dilute ethanol), melting point 254 ℃, insoluble in water, slightly soluble in hot water, first blood-red, then red-purple, hydrolyzed with alcoholic dilute hydrochloric acid when hot; obtained different genistein and 1 molecule of glucose, this product is an isoflavone glycoside found in soybean Soya hispi-da, obtained by extraction and used as a reagent. |
| extraction method | weigh 2.0g of crude soybean isoflavone extract in ethanol → ultrasound for 15 min to completely dissolve → centrifuge the solution at 10000 r/min for 10 min → merge the extract, preliminary separation with treated HP-20 Mitsubishi macroporous adsorption resin → rinse with water until the eluent is colorless and clear → elution with ethanol solution with volume fraction of 40% → product |
| use | genistein is used to reverse control of hypercylase and other tyrosine kinase inhibitors. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: It has certain anti-tumor and blood lipid reduction effects. |
| pharmacokinetics | absorption study found that genistein cannot be directly absorbed by the body, but is absorbed in the form of genistein after enzymatic hydrolysis in intestinal bacteria to exert biological activity. |
Last Update：2024-04-09 02:00:09
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GENISTIN
2-Phenylethylchlorodimethylsilane
monosodiumdihydrogenorthophosphate
DICHLOROPHENOLSULFONEPHTHALEIN
咪唑脲
(3-cyclopentylpropyl)(triethoxy)silane
Cinnamic acid hexyl ester
Benzoic acid, 4-[(2-furanylcarbonyl)amino]-, hydrazide (9CI)
Tris(hydroxymethyl) aminomethane
TEA CHLORIDE
2-Phenylethylchlorodimethylsilane
monosodiumdihydrogenorthophosphate
DICHLOROPHENOLSULFONEPHTHALEIN
咪唑脲
(3-cyclopentylpropyl)(triethoxy)silane
Cinnamic acid hexyl ester
Benzoic acid, 4-[(2-furanylcarbonyl)amino]-, hydrazide (9CI)
Tris(hydroxymethyl) aminomethane
TEA CHLORIDE