Name | 1,4-Dioxan-2,5-dione |
Synonyms | MA4c1357 GLYCOLIDE Glycollide GLYCOLIDE A GLYCOLIDE USP PURASORB(R) G p-Dioxane-2,5-dione 1,4-Dioxan-2,5-dione 1,4-Dioxane-2,5-dione 1,4-DIOXANE-2,5-DIONE 2,5-dioxo-1,4-dioxane 1,4-DIOXANE-2,5-DIONE(GLYCOLIDE) Acetic acid, hydroxy-, bimol. cyclic ester |
CAS | 502-97-6 |
EINECS | 207-954-9 |
InChI | InChI=1/C4H4O4/c5-3-1-7-4(6)2-8-3/h1-2H2 |
InChIKey | RKDVKSZUMVYZHH-UHFFFAOYSA-N |
Molecular Formula | C4H4O4 |
Molar Mass | 116.07 |
Density | 1.423g/cm3 |
Melting Point | 81-83℃ |
Boling Point | 322.5°C at 760 mmHg |
Flash Point | 181.5°C |
Water Solubility | Dichloromethane (Slightly), DMSO (Slightly) |
Vapor Presure | 0.000279mmHg at 25°C |
Appearance | Form Solid color White to Off-White |
Storage Condition | -20°C |
Refractive Index | 1.45 |
MDL | MFCD00081108 |
Physical and Chemical Properties | Biodegradable material monomer, pharmaceutical intermediate. |
Hazard Symbols | Xi - Irritant![]() |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R36 - Irritating to the eyes R22 - Harmful if swallowed |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
WGK Germany | 3 |
TSCA | Yes |
HS Code | 29322090 |
Reference Show more | 1. Li, Yong, et al. "Investigation on complex coacervation between fish skin gelatin from cold-water fish and gum arabic: Phase behavior, thermodynamic, and structural properties." Food Research International 107 (2018): 596-604.https://doi.org/10.1016/j.food |
Overview 1, 4-Dioxylene-2, 5-hexandione is a cyclic ester produced by the dehydration of two molecules of glycolic acid. It is a monomer used to prepare polyglycolic acid (PGA).
Application
1, 4-dioxyl-2, 5-hexanedione is a cyclic ester produced by the dehydration of two molecules of glycolic acid, which can be used as an intermediate in organic synthesis.
preparation: 50g of glycolic acid is weighed and put into a 500 ml double-mouth flask, then 0.05g of phenylalanine stannous catalyst (0.1wt%) is added, prepolymerized at normal pressure and 120 ℃ for 0.5h, then the temperature is increased to 160 ℃, vacuum water is removed through a vacuum distillation device, and the reaction is about 2h until anhydrous discharge is performed to obtain white oligomer. Then 1,4-dioxane -2,5-hexandione was collected by decompression lysis at 260 ℃, and 33.9g of crude 1,4-dioxane -2,5-hexandione was received for 5h. The yield of the product was 89%, and the melting point of the product was 90.6 ℃.
Uses As a degradable polymer material, it has important applications in the medical field, such as surgical sutures, artificial skin and blood vessels, bone fixation and repair, drug controlled release, tissue engineering, etc.
glycolide is abbreviated as GA, a biodegradable material with the molecular formula C4H4O4. As a polymeric monomer, it can not only homopolymerize to obtain polyglycolide, but also ring-opening copolymerization with other cyclic monomers to obtain random copolymers or block copolymers, which are used as biodegradable polymer materials One of them occupies an important position in the research and development of medical polymer materials, and has been applied in many fields such as surgical sutures, artificial skin and blood vessels, bone fixation and repair, drug controlled release, and tissue engineering.
Product parameters
Appearance: white crystalline solid
Purity: ≥ 99.5%
Free acid content: ≤ 1mEq/Kg
Melting point: 82~86 ℃
Water content:<0.02%
Heavy metal content: ≤ 10ppm