GSK-137647A
GSK137647A
CAS: 349085-82-1
Molecular Formula: C16H19NO3S
GSK-137647A - Names and Identifiers
| Name | GSK137647A |
| Synonyms | CS-2460 GSK137647 GSK 137647 GSK-137647 GSK137647A GSK-137647A GSK 137647A FFA4 (GPR120) agonist GS137647A |
| CAS | 349085-82-1 |
GSK-137647A - Physico-chemical Properties
| Molecular Formula | C16H19NO3S |
| Molar Mass | 305.39 |
| Density | 1.214±0.06 g/cm3(Predicted) |
| Boling Point | 438.1±55.0 °C(Predicted) |
| Solubility | DMSO: ≥ 32 mg/mL; H2O: < 0.06 mg/mL (Need ultrasonic and warming) |
| Appearance | powder |
| Color | white to beige |
| pKa | 9.23±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
GSK-137647A - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.274 ml | 16.372 ml | 32.745 ml |
| 5 mM | 0.655 ml | 3.274 ml | 6.549 ml |
| 10 mM | 0.327 ml | 1.637 ml | 3.274 ml |
| 5 mM | 0.065 ml | 0.327 ml | 0.655 ml |
Last Update：2024-01-02 23:10:35
GSK-137647A - Reference Information
| Use | 4-methoxy-n-(2,4, 6-trimethylbenzene) benzenesulfonamide is a typical sulfonamide compound and can be used to prepare dopamine D3 receptor agonists. |
| preparation | add 2,4, 6-trimethylaniline in 200 mL of dichloromethane, ice salt bath cooling to 0 ℃, dropwise addition of p-methoxybenzenesulfonyl chloride dichloromethane solution, heating Reflux reaction 6 h, the reaction solution was poured into crushed ice, ethyl acetate extraction 3 times, the organic phase was combined, the solvent was removed under reduced pressure, the concentrated solution was taken out of ethyl acetate, washed with brine, separated, concentrated filtrate, and recrystallized from ethyl acetate to give 4-methoxy-n-(2,4, 6-trimethylbenzene) benzenesulfonamide solid. |
| biological activity | GSK137647A (GSK 137647) is a free fatty acid receptor 4 (FFA4/GPR120) A selective non-carboxyl agonist with an EC50 value of 501 nM. |
| Target | TargetValue GPR120 () |
| Target | Value |
Last Update：2024-04-09 21:04:16
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Spot supply
Product Name: GSK137647A Visit Supplier Webpage Request for quotationCAS: 349085-82-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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