GSK591(EPZ015866,GSK3203591)
EPZ015866
CAS: 1616391-87-7
Molecular Formula: C22H28N4O2
GSK591(EPZ015866,GSK3203591) - Names and Identifiers
GSK591(EPZ015866,GSK3203591) - Physico-chemical Properties
| Molecular Formula | C22H28N4O2 |
| Molar Mass | 380.48 |
| Density | 1.252±0.06 g/cm3(Predicted) |
| Boling Point | 648.4±55.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| Appearance | powder |
| Color | white to beige |
| pKa | 13.54±0.46(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | In in vitro biochemical experiments, GSK591 effectively inhibited the PRMT5/MEP50 complex by methylating H4, with an IC50 of 11 nM. In Z-138 cells, GSK591 inhibits symmetric methylation of arginine by SmD3 with an EC50 of 56 nM. |
GSK591(EPZ015866,GSK3203591) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.628 ml | 13.141 ml | 26.282 ml |
| 5 mM | 0.526 ml | 2.628 ml | 5.256 ml |
| 10 mM | 0.263 ml | 1.314 ml | 2.628 ml |
| 5 mM | 0.053 ml | 0.263 ml | 0.526 ml |
Last Update：2024-01-02 23:10:35
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CAS: 1616391-87-7
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CAS: 1616391-87-7
Tel: 18301782025
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Mobile: 18021002903
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