GSK621

Name	GSK621
Synonyms	GSK621 GSK621 (GSK 621 6-Chloro-5-(2'-hydroxy-3'-methoxy-[1,1'-biphenyl]-4-yl)-3-(3-methoxyphenyl)-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione 1H-Pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione, 6-chloro-5-(2'-hydroxy-3'-methoxy[1,1'-biphenyl]-4-yl)-3-(3-methoxyphenyl)-
CAS	1346607-05-3

biological activity	GSK621 is a specific AMPK agonist with an IC50 value of 13-30 μm for AML cell lines. GSK621 can induce autophagy and apoptosis. GSK621 induces phosphorylation of eiF2α, a marker of UPR activation.
Cell Line:	MV4-11, OCI-AML3, OCI-AML2, HL-60, Kasumi, HEL, UT7, NB4, TF-1, KG1A, Nomo p28, SKM-1, U937, YHP1, MOLM-14, Mo7e, K562, MOLM-13, EOL-1, SET-2 AML cell lines. 0-30 μM. AML cell lines and primary AML samples.
Concentration:	0-30 μM. 30 μM.
Incubation Time:	4 d. 24 h.
Result:	IC 50 values ranged from 13 to 30 μM. Reduced the proliferation of all 20 lines and increased apoptosis in 17 (85%) lines. Induced the formation of numerous intracytoplasmic vacuoles including autophagosomes. Reduced leukemia growth and significantly extended survival compared to vehicle-treated animals or those treated with 10 mg/kg twice daily.
Animal Model:	MOLM-14 cells xenografted into nude mice.
Dosage:	30 mg/kg.
Administration:	IP twice daily.

Last Update：2024-04-09 21:54:55

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CAS: 1346607-05-3
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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GSK621

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