GW647
GW7647
CAS: 265129-71-3
Molecular Formula: C29H46N2O3S
GW647 - Names and Identifiers
GW647 - Physico-chemical Properties
| Molecular Formula | C29H46N2O3S |
| Molar Mass | 502.75 |
| Density | 1.12 |
| Melting Point | 156 - 157°C |
| Boling Point | 693.9±55.0 °C(Predicted) |
| Solubility | DMSO: 16 mg/mL, soluble |
| Appearance | White solid |
| Color | white |
| pKa | 3.79±0.10(Predicted) |
| Storage Condition | Store at RT |
| In vitro study | GW7647 (1 μM) causes a significant increase of PDZK1 protein expression to 129.7 ± 6.5% of vehicle treated control in Caco2BBE cells in the absence and presence of IL-1β. GW7647 also attenuates the IL-1β-mediated decrease in PDZK1 expression. GW7647 (50 nM) stimulates the PI3K phosphorylation followed by the Akt (Ser473) phosphorylation, which induces NOS1 phosphorylation increased the amounts of NO released in the stripped antral mucosa. GW7647 (50 nM) enhances the initial phase of Ca 2+ -regulated exocytotic events stimulated by ACh in antral mucous cells, but GW7647 alone does not evoke any exocytotic event. GW7647 plus ACh stimulates the effects of wortmannin (50 nM) and AKT-inh (100 nM) on the exocytotic events in antral mucous cells. GW 7647 (100 nM) reduces the AQP9 protein abundance by 43%, but it shows not significant effect at 10 and 1,000 nM in WIF-B9 hepatocytes. GW 7647 (100 nM) causes a 24% reduction in AQP9 protein abundance in HepG2 cells, however, it does not significantly increase the protein abundance of L-FABP in HepG2 hepatocytes. |
| In vivo study | GW7647 (3 mg/kg per day) does not prevent the development of cardiac hypertrophy, but it prevents the decline in left ventricular ejection fraction in vivo. |
GW647 - Risk and Safety
| WGK Germany | 3 |
GW647 - Introduction
GW7647 is an organic compound with the following chemical structure:
This is a thiol compound with the following properties:
-Appearance: A colorless crystalline solid.
-Solubility: Soluble in some organic solvents, such as ethanol, ether solvents.
-Melting point: About 80-85 ° C.
-Stability: relatively stable at room temperature, but may be affected by light, oxygen and high temperature.
GW7647 can be used for the following:
-Drug synthesis: As an intermediate, it can be used to synthesize compounds with specific biological activities.
-Organic photoelectric materials: used to prepare photoelectric materials, such as organic light-emitting diodes (OLED), organic solar cells, etc.
-Preservative: Due to the existence of its thiol group, it has certain anti-corrosion properties and can be used for anti-corrosion coatings, anti-corrosion glue, etc.
The compound can be prepared by the following steps:
1. First, adipic anhydride and 2-amino ethyl benzene as starting materials, through the acylation reaction synthesis intermediates.
2. Then, the synthesized intermediate is subjected to an amidation reaction with cyclohexylamine to obtain the target product.
When using and storing this compound, the following safety information is required:
-Avoid contact with skin and eyes and wear appropriate protective equipment.
-Maintain good ventilation during operation and avoid inhaling gases or volatiles.
-Emissions and disposal are subject to environmental regulations.
-It should be operated in accordance with safe operating procedures to reduce potential hazards.
-Avoid contact with flammable substances during carrying and storage to avoid fire or explosion hazards.
This is a thiol compound with the following properties:
-Appearance: A colorless crystalline solid.
-Solubility: Soluble in some organic solvents, such as ethanol, ether solvents.
-Melting point: About 80-85 ° C.
-Stability: relatively stable at room temperature, but may be affected by light, oxygen and high temperature.
GW7647 can be used for the following:
-Drug synthesis: As an intermediate, it can be used to synthesize compounds with specific biological activities.
-Organic photoelectric materials: used to prepare photoelectric materials, such as organic light-emitting diodes (OLED), organic solar cells, etc.
-Preservative: Due to the existence of its thiol group, it has certain anti-corrosion properties and can be used for anti-corrosion coatings, anti-corrosion glue, etc.
The compound can be prepared by the following steps:
1. First, adipic anhydride and 2-amino ethyl benzene as starting materials, through the acylation reaction synthesis intermediates.
2. Then, the synthesized intermediate is subjected to an amidation reaction with cyclohexylamine to obtain the target product.
When using and storing this compound, the following safety information is required:
-Avoid contact with skin and eyes and wear appropriate protective equipment.
-Maintain good ventilation during operation and avoid inhaling gases or volatiles.
-Emissions and disposal are subject to environmental regulations.
-It should be operated in accordance with safe operating procedures to reduce potential hazards.
-Avoid contact with flammable substances during carrying and storage to avoid fire or explosion hazards.
Last Update：2024-04-09 21:04:16
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CAS: 265129-71-3
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CAS: 265129-71-3
Tel: 18301782025
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QQ: 3008007409
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Product Name: GW7647 Visit Supplier Webpage Request for quotation
CAS: 265129-71-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 265129-71-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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