Gigantic
Gigantol(Dendrophenol)
CAS: 67884-30-4
Molecular Formula: C16H18O4
Gigantic - Names and Identifiers
Gigantic - Physico-chemical Properties
| Molecular Formula | C16H18O4 |
| Molar Mass | 274.31 |
| Density | 1.204±0.06 g/cm3(Predicted) |
| Melting Point | 95-96°C |
| Boling Point | 454.1±40.0 °C(Predicted) |
| Solubility | DMSO : ≥ 100 mg/mL (364.55 mM) |
| Appearance | Liquid |
| pKa | 9.63±0.10(Predicted) |
| Storage Condition | 2-8℃ |
| MDL | MFCD11100326 |
| Physical and Chemical Properties | White crystals, soluble in methanol, ethyl acetate, almost insoluble in water, from Dendrobium nobile. |
| In vitro study | Gigantol decreases the level of phosphorylated LRP6 and cytosolic β-catenin in HEK293 cells. In breast cancer MDA-MB-231 and MDA-MB-468 cells, treatment with gigantol reduces the level of phosphorylated LRP6. Gigantol significantly inhibits the proliferation and induces apoptosis of the HepG2 cells. Gigantol at concentrations of 1, 40 and 150 µM markedly decreases the cell viability by 11.7, 30.0 and 56.4% at 24 h and 21.1, 66.8 and 85.5% at 48 h, respectively. The IC 50 value is 9.30 µM. |
| In vivo study | LDD and gigantol (25–100 mg/kg, p.o.) significantly increase the hot-plate latency in comparison to vehicle-treated mice and decreased carrageenaninduced inflammation in rats. |
Gigantic - Reference
| Reference Show more | 1. Zhang Mei, Li Chunxia, Wei Fang, et al. Protective effect of Dendrobium on human retinal microvascular endothelial cells induced by high glucose [J]. International Journal of Ophthalmology, 2019, 19(02):40-44. 2. Fan Zhao-Yang, Xian Wen-feng, Liu Yong-Xi, et al. Dendrobium phenol inhibits proliferation, migration and invasion of osteosarcoma cells through NF-κB/PRL-3 pathway [J]. Chinese Journal of tumor Biotherapy, 2019, 26 (10). 3. Yu, Shubin, et al. Gigantol inhibitors Wnt/β-catenin signaling and exhibits activity in breast cancer cells."BMC complete and alternative medicine 18.1 (2018): 1-8.https:// doi.org/10.1186/s12906-018-2108-x 4. [IF = 3.659] Yu Shubin et al."Gigantol inhibits Wnt/β-catenin signaling and exhibits anticancer activity in breast cancer cells."Bmc Complem Altern M. 2018 Dec;18(1):1-8 5. [IF=5.037] Jiahui Huang et al."Gigantol inhibits proliferation and enhances DDP-induced apoptosis in breast-cancer cells by downregulating the PI3K/Akt/mTOR signaling pathway."Life Sci. 2021 Jun;274:119354 |
Gigantic - Reference Information
| biological activity | Gigantol is a bibenzyl compound from several medicinal orchid species. Gigantol has anti-tumor activity. Gigantol is an inhibitor of the Wnt/β-catenin pathway. |
| Target | Wnt |
| uses | Dendrobium phenol has the effects of Immunoregulation, antitumor, hypolipidemic and hypoglycemic. for content determination/identification/pharmacological experiments. |
Last Update：2024-04-09 02:00:09
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