Glasdegib
PF-04449913
CAS: 1095173-27-5
Molecular Formula: C21H22N6O
Glasdegib - Names and Identifiers
| Name | PF-04449913 |
| Synonyms | CS-1041 EOS-60832 Glasdegib PF-04449913 PF 04449913 Glasdegib (PF-04449913) N-[(2R,4R)-2-(1H-Benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N'-(4-cyanophenyl)urea 1-((2R,4R)-2-(1H-benzo[d]iMidazol-2-yl)-1-Methylpiperidin-4-yl)-3-(4-cyanophenyl)urea N-[(2R,4R)-2-(1H-Benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N'-(4-cyanophenyl)urea PF 04449913 |
| CAS | 1095173-27-5 |
Glasdegib - Physico-chemical Properties
| Molecular Formula | C21H22N6O |
| Molar Mass | 374.44 |
| Density | 1.33±0.1 g/cm3(Predicted) |
| Melting Point | >214°C (dec.) |
| Boling Point | 633.4±55.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| Appearance | Solid |
| Color | Off-White |
| pKa | 11.93±0.10(Predicted) |
| Storage Condition | -20°C Freezer |
| In vitro study | In the in vitro microsomal assay, PF-04449913 had high clearance in rat microsomes and low clearance in dog and human microsomes without affecting any of the major cytochrome P450 isoforms. |
| In vivo study | In rats and dogs, PF-04449913 shows high clearance and good oral bioavailability. |
Glasdegib - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.671 ml | 13.353 ml | 26.707 ml |
| 5 mM | 0.534 ml | 2.671 ml | 5.341 ml |
| 10 mM | 0.267 ml | 1.335 ml | 2.671 ml |
| 5 mM | 0.053 ml | 0.267 ml | 0.534 ml |
Last Update：2024-01-02 23:10:35
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CAS: 1095173-27-5
Tel: 18301782025
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Mobile: 18021002903
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CAS: 1095173-27-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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