Glaucocalyxin
Glaucocalyxin A
CAS: 79498-31-0
Molecular Formula: C20H28O4
Glaucocalyxin - Names and Identifiers
Glaucocalyxin - Physico-chemical Properties
| Molecular Formula | C20H28O4 |
| Molar Mass | 332.43 |
| Density | 1.22±0.1 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 219.5-220.5℃ (ethyl ether ) |
| Boling Point | 513.4±50.0 °C(Predicted) |
| Specific Rotation(α) | (c, 0.34 in MeOH)-170 |
| Solubility | Very slightly soluble (0.96 g/L) (25 °C) |
| Appearance | White powder |
| pKa | 13.15±0.70(Predicted) |
| Storage Condition | 2-8℃ |
| MDL | MFCD00915351 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, comes from Labiatae plant blue calyx fragrant tea vegetable Rabdosia japonica whole grass, Rabdosia rubescens. |
| In vitro study | Glaucocalyxin A induces apoptosis by mitochondrial apoptotic pathway through several steps including increasing the Bax/Bcl-2 ratio, triggering the intracellular reactive oxygen species (ROS) generation, reducing mitochondrial membrane potential (MMP), and inducing cleavage of caspase-9 and caspase-3. |
Glaucocalyxin - Reference
| Reference Show more | 1. Pu Yihua, Wang Zhiguang, Jiang Jingzhi, Wang Chongyang, Pu Hongmei, Yanguang Hai. Cyanocalyxin a alleviates ovalbumin-induced airway inflammation in asthmatic mice via HMGB1/TLR4/NF-κB signaling pathway [J]. International Journal of Pharmaceutical Research, 2020,47(09):738-744. 2. Pu Yihua, Song Yilan, Wang Zhiguang, Jiang Jingzhi, Li Li, Xu Chang, Pu Ying, Pu Hongmei, yanguanghai. Cyanocalyxin a alleviates allergic reaction induced by mast cell degranulation by inhibiting HMGB1/TLR4/NF-κB signaling pathway [J]. Chinese Journal of Pharmacy, 2021,56(01):201-207. 3. [IF = 4.858] Wenfeng Lin et al."glaucocalyxin A induces G2/M cell cycle arrest and apoptosis through the PI3K/Akt pathway in human bladder cancer cells." Int J Biol Sci. 2018; 14(4): 418-426 4. [IF = 4.36] Meisong Zhu et al."Glaucocalyxin A suppresses osteoclastogenesis induced by RANKL and osteoporosis induced by ovariectomy by inhibiting the NF-κB and Akt pathways."J Ethnopharmacol. 2021 Aug;276:114176 5. [IF=3.647] Jiasheng Chen et al."Glaucocalyxin A induces cell cycle arrest and apoptosis via inhibiting NF-κB/p65 signaling pathway in melanoma cells."Life Sci. 2021 Apr;271:119185 6. [IF=2.629] Piao Yihua et al."Glaucocalyxin A Attenuates Allergic Responses by Inhibiting Mast Cell Degranulation through p38MAPK/NrF2/HO-1 and HMGB1/TLR4/NF-κB Signaling Pathways."Evid-Based Compl Alt. 2021;2021:6644751 7. [IF=3.434] Zhu Weidong et al."Glaucocalyxin A Attenuates IL-1β-Induced Inflammatory Response and Cartilage Degradation in Osteoarthritis Chondrocytes via Inhibiting the Activation of NF-κB Signaling Pathway."Dis Markers. 2022;2022:6516246 |
Glaucocalyxin - Introduction
Glaucalyxin A is an organic compound with the chemical name methyl blue calyx. Its main properties include:
1. Appearance: blue crystalline powder.
2. Solubility: low solubility in water, soluble in organic solvents such as ethanol and chloroform.
3. Stability: It is relatively stable under certain temperature and humidity conditions, but it is easy to decompose in the sun.
The main uses of glaucalyxin A are as follows:
1. Stain: Because of its blue color, it is often used as a reagent for cell and tissue staining.
2. Biological indicator: can be used to observe the intracellular reaction of bacteria and other organisms.
3. Biomedical research: used to study the properties and functions of cytochromes and intracellular proteins.
The preparation method of glaucalyxin A mainly includes the following steps:
1. Obtaining raw materials: precursor compounds of glaucalyxin A can be synthesized or purchased.
2. Reaction steps: Raw materials undergo certain reaction steps, such as acylation reaction and reduction reaction, to obtain glaucalyxin A.
3. Refining and drying: The product is subjected to appropriate refining and drying steps to obtain pure Glaucocalyxin A.
regarding the safety information of glaucalyxin A, the following points should be noted:
1. Protective measures: protective glasses and gloves should be worn during operation to ensure good ventilation.
2. Inhalation: avoid inhaling Glaucocalyxin A dust, you can use A respirator for protection.
3. Food and drinking water: do not contact glauocalyxin A with food and drinking water.
4. Storage: Glaucocalyxin A should be stored in A closed container, avoid contact with oxygen, sunlight and moisture.
5. Waste treatment: waste should be treated in accordance with the relevant chemical treatment standards.
1. Appearance: blue crystalline powder.
2. Solubility: low solubility in water, soluble in organic solvents such as ethanol and chloroform.
3. Stability: It is relatively stable under certain temperature and humidity conditions, but it is easy to decompose in the sun.
The main uses of glaucalyxin A are as follows:
1. Stain: Because of its blue color, it is often used as a reagent for cell and tissue staining.
2. Biological indicator: can be used to observe the intracellular reaction of bacteria and other organisms.
3. Biomedical research: used to study the properties and functions of cytochromes and intracellular proteins.
The preparation method of glaucalyxin A mainly includes the following steps:
1. Obtaining raw materials: precursor compounds of glaucalyxin A can be synthesized or purchased.
2. Reaction steps: Raw materials undergo certain reaction steps, such as acylation reaction and reduction reaction, to obtain glaucalyxin A.
3. Refining and drying: The product is subjected to appropriate refining and drying steps to obtain pure Glaucocalyxin A.
regarding the safety information of glaucalyxin A, the following points should be noted:
1. Protective measures: protective glasses and gloves should be worn during operation to ensure good ventilation.
2. Inhalation: avoid inhaling Glaucocalyxin A dust, you can use A respirator for protection.
3. Food and drinking water: do not contact glauocalyxin A with food and drinking water.
4. Storage: Glaucocalyxin A should be stored in A closed container, avoid contact with oxygen, sunlight and moisture.
5. Waste treatment: waste should be treated in accordance with the relevant chemical treatment standards.
Last Update：2024-04-09 21:21:28
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Spot supply
Product Name: Glaucocalyxin A Visit Supplier Webpage Request for quotationCAS: 79498-31-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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