Glu(OtBu)
H-Glu(OtBu)-OH
CAS: 2419-56-9
Molecular Formula: C9H17NO4
Glu(OtBu) - Names and Identifiers
| Name | H-Glu(OtBu)-OH |
| Synonyms | Glu(OtBu) Glu(OtBu)-OH H-Glu(OtBu)-OH L-GLUTAMIC ACID-Y-T-BUTYL ESTER L-Glutamic acid 5-t-Butyl Ester L-Glutamic acid γ-t.-butyl ester L-Glutamic Acid 5-Tert-Butyl Ester L-GLUTAMIC ACID-5-TERT-BUTYL ESTER L-GLUTAMIC ACID-Y-T-BUTYLESTER MONOHYDRATE (2S)-2-ammonio-5-tert-butoxy-5-oxopentanoate GLUTAMIC ACID GAMMA-T-BUTYL ESTER MONOHYDRATE L-Glutamic acid γ-tert·butyl ester monohydrate L-GLUTAMIC ACID .GAMMA.-TERT-BUTYL ESTER MONOHYDRATE |
| CAS | 2419-56-9 |
| EINECS | 607-337-8 |
| InChI | InChI=1/C9H17NO4/c1-9(2,3)14-7(11)5-4-6(10)8(12)13/h6H,4-5,10H2,1-3H3,(H,12,13)/t6-/m0/s1 |
Glu(OtBu) - Physico-chemical Properties
| Molecular Formula | C9H17NO4 |
| Molar Mass | 203.24 |
| Density | 0.992 g/cm3 |
| Melting Point | 182°C(lit.) |
| Boling Point | 110 °C(Press: 0.05 Torr) |
| Flash Point | 157.3°C |
| Water Solubility | Sparingly soluble in water; practically insoluble in ethanol or ether. |
| Vapor Presure | 2.11E-05mmHg at 25°C |
| Appearance | Solid |
| Color | White to Almost white |
| BRN | 2049031 |
| pKa | 2.20±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.475 |
Glu(OtBu) - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R24 - Toxic in contact with skin |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S25 - Avoid contact with eyes. |
| WGK Germany | 3 |
| HS Code | 29224999 |
| Hazard Class | IRRITANT |
Glu(OtBu) - Reference Information
| Application | L-glutamic acid -5-tert-butyl ester is abbreviated as Glu(OtBu), which is an amino acid derivative. L-glutamic acid -5-tert-butyl ester can be obtained by the reaction of glutamic acid and tert-butyl acetate. |
| preparation | add 2324g of tert-butyl acetate and 73.5g of glutamic acid into a 3000mL three-mouth bottle, stir, drop 160.8mL of perchloric acid, react at 10 ℃ for 48 hours, cool to 0 ℃, add 1000mL of water, extract take (the remaining tert-butyl acetate is extracted as solvent), neutralize with Na2CO3 to pH = 8~9, separate the liquid, then wash with 400 mL1%Na2CO3 aqueous solution three times, and concentrate the tert-butyl acetate layer under reduced pressure to obtain 42g of oil Glu(OtBu)2 with a yield of 32.4%. Add 42g of Glu(OtBu)2 into a 1000mL three-mouth bottle, then add 400mL of water and 11g of CuCl2, raise the temperature to 50 ℃, react for 12 hours, and prepare Cu[Glu(OtBu)]x(x = 1~2); When it is reduced to room temperature, add 19g of tetramethylethylenediamine and 100mL of dioxane, and then adjust the pH to 8~9 with triethylamine, L-glutamic acid -5-tert-butyl ester was prepared. |
Last Update：2024-04-10 22:29:15
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