Gramine
Gramine
CAS: 87-52-5
Molecular Formula: C11H14N2
Gramine - Names and Identifiers
| Name | Gramine |
| Synonyms | Gramine TIMTEC-BB SBB003799 3-(dimethylaninomethy)in dole 3-(Dimethylaminomethyl)indole indol-3-ylmethyldimethylamine Indole, 3-[(dimethylamino)methyl]- n,n-dimethyl-1h-indole-3-methanamin N,N-Dimethyl-1H-indole-3-methylamine n,n-dimethyl-1h-indole-3-methanamine |
| CAS | 87-52-5 |
| EINECS | 201-749-8 |
| InChI | InChI=1/C11H14N2/c1-13(2)8-9-7-12-11-6-4-3-5-10(9)11/h3-7,12H,8H2,1-2H3 |
Gramine - Physico-chemical Properties
| Molecular Formula | C11H14N2 |
| Molar Mass | 174.24 |
| Density | 1.0715 (rough estimate) |
| Melting Point | 132-134 °C (lit.) |
| Boling Point | 295.23°C (rough estimate) |
| Flash Point | 167 °C |
| Water Solubility | PRACTICALLY INSOLUBLE |
| Solubility | Soluble in alcohol, ether, chloroform, slightly soluble in cold acetone, almost insoluble in water and petroleum ether |
| Vapor Presure | 0.00168mmHg at 25°C |
| Appearance | Needle crystal |
| Color | Beige |
| Merck | 14,4533 |
| BRN | 140521 |
| pKa | 17.00±0.30(Predicted) |
| Storage Condition | Refrigerator (+4°C) |
| Refractive Index | 1.5500 (estimate) |
| MDL | MFCD00005629 |
| Physical and Chemical Properties | Leaf patchy or needle-like crystals. Melting point 138-139 ℃, soluble in alcohol, ether, chloroform, slightly soluble in cold acetone, almost insoluble in water and petroleum ether. |
| In vitro study | Gramine is an active adiponectin receptor (AdipoR) agonist, with IC 50 s of 3.2 and 4.2 µM for AdipoR2 and AdipoR1, respectively. Gramine is a potential β2-AR agonist. Gramine (20 µM to 1.2 nM) dose-dependently inhibits the growth of AdipoR1/adipoR2-positive cancer cell lines (MDA-MB-231 and MCF-7 cells), with IC 50 s of 9.6±0.9 and 0.1±0.1 µM, respectively. |
Gramine - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | 34 - Causes burns |
| Safety Description | S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | NL7525000 |
| HS Code | 29339900 |
Gramine - Reference
| Reference Show more | 1. Tao Jiayu, Gong, Xiaoyun, zouji, et al. Simultaneous determination of alkaloids and flavonoids in malt total alkaloids extract by HPLC [J]. New drugs of traditional Chinese medicine and clinical pharmacology 2020 v.31;No.166(01):108-110. 2. Zhang Qinghua, Lu Zhi, Zhang Xiaoyang, etc. Bioinformatics analysis and functional analysis of MDR gene in eucalyptus scorch pathogen [J]. Journal of Fujian Agriculture and Forestry University: Natural Science Edition, 2019, 048(001):88-96. 3. Yang, Zehui, Danfeng Shao, and Guoquan Zhou. "Investigation of grainesolubility and Mathematical Modeling in Various Pure solids and the Co-Solvent Mixture of at (273.15-313.15) K." Journal of Chemical & Engineering Data 65.4 ( 4. Yang, Zehui, Danfeng Shao, and Guoquan Zhou. "Investigation of Gramine Solubility and Mathematical Modeling in Various Pure Solvents and the Co-Solvent Mixture of (Ethanol Ethyl Acetate) at (273.15-313.15) K." Journal of Chemical & Engineering Data 65.4 ( |
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View History
Gramine
emulsifier(s65)
UNII-15XUH0X66N
Rubber Antioxidant BLE
N-OCTACOSANOIC ACID
H-pyroGlu-OMe
1-methyl-4-oxonipecotic acid methyl ester hydrochloride
emulsifier(s65)
UNII-15XUH0X66N
Rubber Antioxidant BLE
N-OCTACOSANOIC ACID
H-pyroGlu-OMe
1-methyl-4-oxonipecotic acid methyl ester hydrochloride