H-6-DIAZO-5-OXO-D-NORLEUCINE
6-diazo-5-oxo-D-norleucine
CAS: 71629-86-2
Molecular Formula: C6H9N3O3
H-6-DIAZO-5-OXO-D-NORLEUCINE - Names and Identifiers
| Name | 6-diazo-5-oxo-D-norleucine |
| Synonyms | D-DON H-6-DIAZO-5-OXO-D-NLE-OH H-D-NLE(6-DIAZO-5-OXO)-OH 6-diazo-5-oxo-D-norleucine 6-DIAZO-5-OXO-D-NORLEUCINE H-6-DIAZO-5-OXO-D-NORLEUCINE 6-DIAZO-5-OXO-D-2-AMINOHEXANOIC ACID (R)-2-Amino-6-diazo-5-oxocaproic acid, (R)-6-Diazo-5-oxo-L-norleucine D-DON, 6-Diazo-5-oxo-D-2-aMinohexanoic acid, H-D-Glu(diazoMethylketone)-OH |
| CAS | 71629-86-2 |
| InChI | InChI=1/C6H9N3O3/c7-5(6(11)12)2-1-4(10)3-9-8/h3,5H,1-2,7H2,(H,11,12)/t5-/m1/s1 |
H-6-DIAZO-5-OXO-D-NORLEUCINE - Physico-chemical Properties
| Molecular Formula | C6H9N3O3 |
| Molar Mass | 171.15 |
| Storage Condition | −20°C |
H-6-DIAZO-5-OXO-D-NORLEUCINE - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | 36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
H-6-DIAZO-5-OXO-D-NORLEUCINE - Introduction
6-diazo-5-oxo-D-norleucine, also known as 6-diazo-5-oxo-D-norleucine, is an organic compound. Its chemical formula is C6H9N5O3.
The compound is a white crystal that can be dissolved in water and some organic solvents. It is an antimetabolite and has the effect of inhibiting amino acid metabolism. Therefore, it is widely used to study the metabolic pathways of cancer cells and its potential to treat tumors. In addition, the compound is also useful as an inhibitor of protein-degrading enzymes.
There are two main methods for preparing 6-diazo-5-oxo-D-norleucine. One method is obtained by reacting 2-amino-6-diazo-5-chlorohexanoic acid with NaNO2. Another method is by the diazotization of 6-bromo-5-oxohexanoic acid.
Regarding safety information, 6-diazo-5-oxo-D-norleucine is a toxic compound. In the use of the process, should follow the relevant laboratory safety procedures. It may be irritating to the skin, eyes and respiratory system, and is potentially carcinogenic. Therefore, appropriate protective equipment such as chemical protective gloves, goggles and protective masks should be worn during operation. At the same time, the compound should be stored in a dry, well-ventilated place, away from fire and flammable materials. When disposing of waste, local regulations should be followed.
The compound is a white crystal that can be dissolved in water and some organic solvents. It is an antimetabolite and has the effect of inhibiting amino acid metabolism. Therefore, it is widely used to study the metabolic pathways of cancer cells and its potential to treat tumors. In addition, the compound is also useful as an inhibitor of protein-degrading enzymes.
There are two main methods for preparing 6-diazo-5-oxo-D-norleucine. One method is obtained by reacting 2-amino-6-diazo-5-chlorohexanoic acid with NaNO2. Another method is by the diazotization of 6-bromo-5-oxohexanoic acid.
Regarding safety information, 6-diazo-5-oxo-D-norleucine is a toxic compound. In the use of the process, should follow the relevant laboratory safety procedures. It may be irritating to the skin, eyes and respiratory system, and is potentially carcinogenic. Therefore, appropriate protective equipment such as chemical protective gloves, goggles and protective masks should be worn during operation. At the same time, the compound should be stored in a dry, well-ventilated place, away from fire and flammable materials. When disposing of waste, local regulations should be followed.
Last Update：2024-04-09 21:11:58
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CAS: 71629-86-2
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Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 71629-86-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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