H-Cyclohexyl-Gly-OH
H-Cyclohexyl-Gly-OH
CAS: 14328-51-9
Molecular Formula: C8H15NO2
H-Cyclohexyl-Gly-OH - Names and Identifiers
| Name | H-Cyclohexyl-Gly-OH |
| Synonyms | H-Chg-OH L-Chg-OH·HCl L-Chg-OH·TFA H-Cyclohexyl-Gly-OH L-Cyclohexylglycine (S)-2-Cyclohexylglycine H-L-Cyclohexyl-Gly-OH·TFA (S)-CYCLOHEXYLGLYCINE HCL L-alpha-Cyclohexylglycine H-Cyclohexyl-L-Gly-OH·HCl L-(+)-2-Cyclohexylglycine amino(cyclohexyl)acetic acid (1-ammoniocyclohexyl)acetate (2S)-amino(cyclohexyl)ethanoic acid |
| CAS | 14328-51-9 |
| InChI | InChI=1/C8H15NO2/c9-8(6-7(10)11)4-2-1-3-5-8/h1-6,9H2,(H,10,11) |
| InChIKey | WAMWSIDTKSNDCU-ZETCQYMHSA-N |
H-Cyclohexyl-Gly-OH - Physico-chemical Properties
| Molecular Formula | C8H15NO2 |
| Molar Mass | 157.21 |
| Density | 1.120±0.06 g/cm3(Predicted) |
| Melting Point | 256°C |
| Boling Point | 292.8±23.0 °C(Predicted) |
| Specific Rotation(α) | 34.5 º (c=1, 1N HCl 25 ºC) |
| Flash Point | 131.7°C |
| Water Solubility | Soluble |
| Vapor Presure | 0.000403mmHg at 25°C |
| Appearance | Solid |
| Color | White to Almost white |
| pKa | 2.44±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.492 |
| MDL | MFCD01311679 |
| Physical and Chemical Properties | Melting Point 256°C specific rotation 34.5 ° (c = 1, 1N HCl 25°C) water-Soluble solution |
H-Cyclohexyl-Gly-OH - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S24/25 - Avoid contact with skin and eyes. |
| HS Code | 29224999 |
H-Cyclohexyl-Gly-OH - Reference Information
| introduction | L-cyclohexylglycine has a melting point of 256 degrees and is a white to slightly beige solid powder under normal temperature and pressure. L-cyclohexylglycine is a non-natural amino acid derivative, which is soluble in water and is widely used in the synthesis of biological peptides. |
| Use | L-cyclohexylglycine can be used in the synthesis of therapeutic inhibitors of glutamine cyclase. In the synthesis and transformation, the structure The amino group can be converted into a bromine unit by diazotization, and the carboxyl group can be converted into an amide structure under the action of dichlorosulfoxide. |
| synthesis method | add a magnetic stirring rod to a 10 ml flask, and mix L-phenylglycine [152 mg, 1.00 mmol] and NaOH(0.10 M aq, 10 mL, 1.0 mmol) into a reaction flask under nitrogen environment to prepare L-phenylglycine sodium salt. The obtained salt solution (0.10 M aq,5.0 mL,0.50 mmol) and Ru(0.8wt %)/chitin (50 mg,0.8 mol%Ru) were hydrogenated at 100 degrees for 3 hours to obtain the product. The catalyst was removed by filtration, the product was washed with H2O and THF, respectively, hydrochloric acid (0.5M aq,10mL) was added to the filtrate, the mixture was stirred at room temperature for 1 hour, and concentrated in vacuum to obtain L-Cyclohexylglycine. |
Last Update：2024-04-09 20:52:54
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