H-Glu(OtBu)-OMe.HCl

H-Glu(OtBu)-OMe.HCl - Names and Identifiers

Name	H-Glu(OtBu)-OMe . HCl
Synonyms	H-GLU(OBUT)-OME HCL H-Glu(OtBu)-OMe.HCl H-Glu(OtBu)-OMe·HCl H-Glu(OBut)-OMe*HCl H-GLU(OTBU)-OME HCL H-Glu(OtBu)-OMe . HCl L-(g-O-Bu)-Glu-OMe HCl GLUTAMIC ACID(OTBU)-OME HCL H-GLU(OTBU)-OME HYDROCHLORIDE 5-tert-butyl 1-methyl L-glutamate hydrochloride L-GLUTAMIC ACID 5-TERT-BUTYL 1-METHYL ESTER HYDROCHLORIDE L-Glutamic acid-5-tert-butyl-1-methyl ester hydrochloride L-Glutamic acid 5-tert-butyl 1-methyl ester hydrochloride L-GLUTAMIC ACID GAMMA-T-BUTYL ALPHA-METHYL ESTER HYDROCHLORIDE L-GLUTAMIC ACID-GAMMA-TERT-BUTYL-ALPHA-METHYL ESTER HYDROCHLORIDE L-GLUTAMIC ACID GAMMA-T-BUTYL ESTER ALPHA-METHYL ESTER HYDROCHLORIDE L-GLUTAMIC ACID GAMMA-T-BUTYL ESTER ALPHA-METHYL ESTER HYDROCHLORIDE SALT
CAS	6234-01-1
EINECS	228-348-0
InChI	InChI=1/C10H19NO4.ClH/c1-10(2,3)15-8(12)6-5-7(11)9(13)14-4;/h7H,5-6,11H2,1-4H3;1H/t7-;/m0./s1

H-Glu(OtBu)-OMe.HCl - Physico-chemical Properties

Molecular Formula	C10H20ClNO4
Molar Mass	253.72
Melting Point	128 °C
Boling Point	304.5°C at 760 mmHg
Flash Point	137.9°C
Solubility	Methanol (Slightly), Water
Vapor Presure	0.000651mmHg at 25°C
Appearance	White crystalline powder
Color	White
BRN	3572140
Storage Condition	2-8°C
MDL	MFCD00153438

H-Glu(OtBu)-OMe.HCl - Risk and Safety

Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S4 - Keep away from living quarters. S7 - Keep container tightly closed. S28 - After contact with skin, wash immediately with plenty of soap-suds. S35 - This material and its container must be disposed of in a safe way. S44 -
WGK Germany	3
HS Code	29224999

H-Glu(OtBu)-OMe.HCl - Introduction

Nature:
H-Glu(OtBu)-OMe . HCl is a solid, white crystalline powder at room temperature. Its melting point is usually in the range of 40-45 degrees Celsius. It is slightly soluble in water and easily soluble in some organic solvents, such as methanol and chloroform.

Use:
H-Glu(OtBu)-OMe . HCl is commonly used as a protecting group in organic synthesis, especially in peptide synthesis. It can protect the hydroxyl (-OH) group of natural amino acids from other unnecessary reactions in the reaction. At the same time, it can also be used as an intermediate in drug research.

Preparation Method:
The preparation method of H-Glu(OtBu)-OMe . HCl is complicated and generally needs to be carried out under laboratory conditions.
First, glutamic acid methyl ester is reacted with p-tert-butylammonium chloride (OtBu-NHCOC1) in a solvent to generate OtBu-L-glutamyl methyl ester. This product is then reacted with hydrochloric acid to produce OtBu-L-glutamyl methyl ester hydrochloride, I .e., H-Glu(OtBu)-OMe. HCl.

Safety Information:
H-Glu(OtBu)-OMe . HCl has high safety, but the following matters still need to be paid attention:
1. use to wear appropriate personal protective equipment, such as gloves, protective glasses.
2. Avoid inhaling the dust of the compound and avoid contact with skin and eyes.
3. avoid ingestion during use. If ingested or exposed, seek medical attention immediately and show relevant information.
4. Keep away from fire and oxidant, and store in a dry and cool place.

Last Update：2024-04-09 21:01:54