H2N-PEG4-CH2CH2COOH
α-amine-ω-propionic acid tetraethylene glycol
CAS: 663921-15-1
Molecular Formula: C11H23NO6
H2N-PEG4-CH2CH2COOH - Names and Identifiers
H2N-PEG4-CH2CH2COOH - Physico-chemical Properties
| Molecular Formula | C11H23NO6 |
| Molar Mass | 265.3 |
| Density | 1.134±0.06 g/cm3(Predicted) |
| Boling Point | 409.6±40.0 °C(Predicted) |
| pKa | 4.28±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Physical and Chemical Properties | Bioactive NH2-PEG4-CH2CH2COOH is a degradable (cleavable) 4-unit PEG-like ADC linker used in the synthesis of antibody-coupled drugs (ADCs). NH2-PEG4-CH2CH2COOH is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis. |
| In vitro study | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
H2N-PEG4-CH2CH2COOH - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.769 ml | 18.847 ml | 37.693 ml |
| 5 mM | 0.754 ml | 3.769 ml | 7.539 ml |
| 10 mM | 0.377 ml | 1.885 ml | 3.769 ml |
| 5 mM | 0.075 ml | 0.377 ml | 0.754 ml |
Last Update：2024-01-02 23:10:35
H2N-PEG4-CH2CH2COOH - Uses and synthesis methods
target
Cleavable
PEGs
in vitro study
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Last Update：2024-04-09 21:01:54
H2N-PEG4-CH2CH2COOH - Reference Information
| biological activity | NH2-PEG4-CH2CH2COOH is a degradable (cleavable) 4-unit PEG-like ADC linker, for the synthesis of antibody-conjugated drugs (ADCS). NH2-PEG4-CH2CH2COOH is also a PEG-based PROTAC linker and can be used in the synthesis of PROTAC. |
| Target | Cleavable PEGs |
| in vitro study | ADCs are combined of an antibody to which is attached an ADC cytoxin through an ADC linker. PROTACs contains two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intrinsic ubiquitin-proteasome system to selective grade target proteins. |
Last Update：2024-04-09 20:49:11
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Product Name: α-Amine-ω-propionic acid tetraethylene glycol Visit Supplier Webpage Request for quotationCAS: 663921-15-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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