Molecular Formula | C19H39NO8 |
Molar Mass | 409.51 |
Density | 1.056±0.06 g/cm3(Predicted) |
Boling Point | 475.9±40.0 °C(Predicted) |
pKa | 8.74±0.10(Predicted) |
Storage Condition | -20°C |
In vitro study | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
biological activity | NH2-PEG6-Boc is a PROTAC linker, belonging to the PEG class. NH2-PEG6-Boc can be used to synthesize PROTAC molecules. NH2-PEG6-Boc is also a non-cleavable ADC linker containing 6-unit PEG, which can be used to synthesize antibody-coupled drugs (ADC). |
target | PEGs Alkyl/ether Non-cleavable |
in vitro research | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |