HA130 - Names and Identifiers
HA130 - Physico-chemical Properties
Molecular Formula | C24H19BFNO5S
|
Molar Mass | 463.29 |
Storage Condition | 2-8℃ |
In vitro study | HA130 completely blocks the ability of ATX to promote TEM (transendothelial migration). HA130 at 0.3 μM completely ablates the activity of ATX on TK1 uropod formation. |
In vivo study | HA130 slows T cell migration across lymph node HEVs. HA130 decreases the "outside HEVs/inside HEVs" ratio by 3-4-fold compared to vehicle-treated animals vehicle. The s.c. administration of HA130 induces marked lymphocyte accumulation within the endothelial cell (EC) and sub-EC layers of HEVs in draining lymph nodes (LNs). |
HA130 - Preparation solution concentration reference
| 1mg | 5mg | 10mg |
---|
1 mM | 2.158 ml | 10.792 ml | 21.585 ml |
5 mM | 0.432 ml | 2.158 ml | 4.317 ml |
10 mM | 0.216 ml | 1.079 ml | 2.158 ml |
5 mM | 0.043 ml | 0.216 ml | 0.432 ml |
Last Update:2024-01-02 23:10:35
HA130 - Reference Information
biological activity | HA130 is a selective autotaxin (ATX) inhibitor with IC50 of 28 nM. |
target | Autotaxin 28 nM (IC 50 ) |
in vitro study | HA130 completely blocks the ability of ATX to promote TEM (transendothelial migration). HA130 at 0.3 μM completely ablates the activity of ATX on TK1 uropod formation. |
in vivo study | HA130 slow T cell migration across lymph node HEVs. HA130 decreases the "outside HEVs/inside HEVs" ratio by 3-4-fold compared to vehicle-treated animals vehicle. The s.c. administration of HA130 induces marked lymphocyte accumulation with the endothelial cell (EC) and sub-EC layers of HEVs in draining Lmph nodes (LNs). |
Last Update:2024-04-09 20:52:54