HC≡C-CH2-PEG6-NH2
Propargyl-PEG5-amine
CAS: 1589522-46-2
Molecular Formula: C13H25NO5
HC≡C-CH2-PEG6-NH2 - Names and Identifiers
| Name | Propargyl-PEG5-amine |
| Synonyms | Alkyne-PEG5-NH2 HC≡C-CH2-PEG6-NH2 PROPARGYL-PEG5-NH2 Propargyl-PEG5-amine 3,6,9,12,15-Pentaoxaoctadec-17-yn-1-amine |
| CAS | 1589522-46-2 |
HC≡C-CH2-PEG6-NH2 - Physico-chemical Properties
| Molecular Formula | C13H25NO5 |
| Molar Mass | 275.34 |
| Density | 1.049±0.06 g/cm3(Predicted) |
| Boling Point | 360.4±37.0 °C(Predicted) |
| Solubility | DMSO : 80 mg/mL mother liquor preservation: sub-package and freeze storage to avoid repeated freezing and thawing;-20 ℃,1 month;-80 ℃,6 months (after dilution, the solution temperature is low, storage may precipitate, try to use it now) |
| pKa | 8.74±0.10(Predicted) |
| Storage Condition | -20 ℃, dark |
| Use | Propargyl-PEG5-amine is a PEG derivative containing a propargyl group and an amine group. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. PEG Linkers can be useful in the development of antibody drug conjugates (ADCs). |
| Target | PEGs； Non-cleavable |
| In vitro study | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
HC≡C-CH2-PEG6-NH2 - Reference
| Reference Show more | 1: Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc400050k. Epub 2013 May 3. PubMed PMID: 23600922; PubMed Central PMCID: PMC3674550. 2: Harrison E, Coulter JA, Dixon D. Gold nanoparticle surface functionalization: mixed monolayer versus hetero bifunctional peg linker. Nanomedicine (Lond). 2016 Apr;11(7):851-65. Review. PubMed PMID: 27021417. 3: Augusto MT, Hollmann A, Porotto M, Moscona A, Santos NC. Antiviral Lipopeptide-Cell Membrane Interaction Is Influenced by PEG Linker Length. Molecules. 2017 Jul 15;22(7). pii: E1190. doi: 10.3390/molecules22071190. PubMed PMID: 28714870; PubMed Central PMCID: PMC5776016. 4: Tuma R, Russell M, Rosendahl M, Thomas GJ Jr. Solution conformation of the extracellular domain of the human tumor necrosis factor receptor probed by Raman and UV-resonance Raman spectroscopy: structural effects of an engineered PEG linker. Biochemistry. 1995 Nov 21;34(46):15150-6. PubMed PMID: 7578129. |
HC≡C-CH2-PEG6-NH2 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.632 ml | 18.159 ml | 36.317 ml |
| 5 mM | 0.726 ml | 3.632 ml | 7.263 ml |
| 10 mM | 0.363 ml | 1.816 ml | 3.632 ml |
| 5 mM | 0.073 ml | 0.363 ml | 0.726 ml |
Last Update：2024-01-02 23:10:35
HC≡C-CH2-PEG6-NH2 - Reference Information
| biological activity | Propargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-coupled drugs (ADCs). Propargyl-PEG5-amine is a PROTAC linker and belongs to the PEG class. Propargyl-PEG5-NH2 can be used to synthesize a series of PROTAC molecules. |
| target | Non-cleavable PEGs |
| in vitro study | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
Last Update：2024-04-09 21:11:58
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