HELENALIN(SH)
Helenalin
CAS: 6754-13-8
Molecular Formula: C15H18O4
HELENALIN(SH) - Names and Identifiers
HELENALIN(SH) - Physico-chemical Properties
| Molecular Formula | C15H18O4 |
| Molar Mass | 262.3 |
| Density | 1.0772 (rough estimate) |
| Melting Point | 167-168° |
| Boling Point | 325.55°C (rough estimate) |
| Specific Rotation(α) | D25 -102.8° (c = 3.64 in 95% ethanol) |
| Solubility | Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml). |
| Appearance | Solid |
| Color | White |
| pKa | 13.29±0.60(Predicted) |
| Storage Condition | -20° |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| Refractive Index | 1.4300 (estimate) |
HELENALIN(SH) - Risk and Safety
| UN IDs | 2811 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 in mice, rats (mg/kg): 150, 125 orally (Witzel) |
HELENALIN(SH) - Reference Information
| biological activity | Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits the transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity that targets the cysteine thiol group in the p65 subunit of NF-κB, thereby inhibiting its DNA binding. |
| Cell Line: | Jurkat T cells |
| Concentration: | 10 μM |
| Incubation Time: | 20-120 minutes |
| Result: | Caused complete inhibition of NF-κB DNA binding after 80 minutes. Caused a rapid decrease in hepatic glutathione levels. |
| Animal Model: | Immature male ICR mice |
| Dosage: | 25 mg/kg |
| Administration: | i.p.; 6 to 12 hours |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 19:05:17
