HIRSUTINE
Hirsutine
CAS: 7729-23-9
Molecular Formula: C22H28N2O3
HIRSUTINE - Names and Identifiers
HIRSUTINE - Physico-chemical Properties
| Molecular Formula | C22H28N2O3 |
| Molar Mass | 368.47 |
| Density | 1.20±0.1 g/cm3(Predicted) |
| Melting Point | 101 °C |
| Boling Point | 531.7±50.0 °C(Predicted) |
| Specific Rotation(α) | (c, 0.32 in CHCl3)+68.6 |
| Solubility | Soluble in methanol, acid water, chloroform |
| Appearance | White powder or crystal |
| pKa | 18.13±0.60(Predicted) |
| Storage Condition | 2-8℃ |
| MDL | MFCD01750089 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from uncaria Uncaria rhynchophylla(Miq.)Miq. ex Havil.. |
| In vitro study | Hirsutine remarkably reduces the viability of MCF-7 and MDA-MB-231 cells in a time- and dose-dependent manner with IC 50 values of 447.79 and 179.06 μM, respectively. In the MDA-MB-231 cells, Hirsutine induces apoptosis and depolarization of MMP, releases Cyt C from mitochondria, and activates caspase 9 and caspase 3. |
| In vivo study | Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells. |
HIRSUTINE - Reference
| Reference Show more | 1. Guo Xiaomin, Huang Baoyuan, Zeng Chang Qing. Screening of Uncaria alkaloid extract and its monomer to reverse drug resistance activity of HepG2/ADM cells [J]. Journal of Guangdong Pharmaceutical College, 2018, 034(004):447-451. 2. [IF = 4.411] Shugen Wei et al."Molecular Identification and Targeted Quantitative Analysis of Medicinal Materials from Uncaria Species by DNA Barcoding and LC-MS/MS." Molecules. 2019 Jan;24(1):175 3. [IF = 4.759] Keyu Feng et al."Configuration of the ion exchange chromatography, and reversed-phase chromatography as off-line three-dimensional chromatography coupled with high-resolution quadrupole-Orbitrap mass spectrometry fo 4. [IF=6.529] Lingling Xie et al."Uncaria Rhynchophylla attenuates angiotensin Ⅱ-induced myocardial fibrosis via suppression of the RhoA/ROCK1 pathway."Biomed Pharmacother. 2022 Feb;146:112607 |
HIRSUTINE - Reference Information
| Use | rhynchophylline belongs to the tetracyclic hetero-yohimbine alkaloid. Rhynchophylline is mainly found in the leaves of Uncaria and Galea. Modern pharmacological studies have shown that rhynchophylline has anti-arrhythmia, anti-myocardial ischemia, anti-influenza Virus, anti-acetylcholine, antispasmodic and local anesthetic effects and activity. for content determination/identification/pharmacological experiments, etc |
| biological activity | Hirsutine, an indole alkaloid of Uncaria rhynchophylla, has anti-cancer activity. Hirsutine induces apoptosis and is a potent inhibitor of Dengue virus with low toxicity. |
Last Update：2024-04-09 21:54:55
Supplier List
Spot supply
Product Name: Mitragynine Impurity 8 (Hirsutine) Visit Supplier Webpage Request for quotationCAS: 7729-23-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Hirsutine Visit Supplier Webpage Request for quotationCAS: 7729-23-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Mitragynine Impurity 8 (Hirsutine) Visit Supplier Webpage Request for quotationCAS: 7729-23-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Hirsutine Visit Supplier Webpage Request for quotationCAS: 7729-23-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History