HS-173
HS-173
CAS: 1276110-06-5
Molecular Formula: C21H18N4O4S
HS-173 - Names and Identifiers
HS-173 - Physico-chemical Properties
| Molecular Formula | C21H18N4O4S |
| Molar Mass | 422.46 |
| Density | 1.38±0.1 g/cm3(Predicted) |
| Melting Point | >193°C (dec.) |
| Solubility | Chloroform (Slightly), DMSO (Slightly) |
| Appearance | Solid |
| Color | Grey to Brown |
| pKa | 6.84±0.40(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | HS-173 showed potent anti-proliferative effects in T47D,SK-BR3, and MCF7 cells with IC50 of 0.6,1.5, and 7.8 μm, respectively. HS-173 completely inhibited the PI3K pathway in cancer cell lines (Hep3B and SkBr3). In addition, in in vitro assays, HS-173 induced apoptosis and blocked VEGF-induced angiogenesis by affecting cell cycle distribution and activating caspases. Sorafenib and HS-173 combination therapy has a synergistic anti-cancer effect on pancreatic cancer cells. |
| In vivo study | HS-173 reduce blood vessel formation in mice. HS-173 significantly attenuates the development of liver fibrosis in vivo by blocking PI3K/Akt signaling. |
HS-173 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.367 ml | 11.835 ml | 23.671 ml |
| 5 mM | 0.473 ml | 2.367 ml | 4.734 ml |
| 10 mM | 0.237 ml | 1.184 ml | 2.367 ml |
| 5 mM | 0.047 ml | 0.237 ml | 0.473 ml |
Last Update：2024-01-02 23:10:35
HS-173 - Introduction
HS-173 is a chemical substance whose chemical name is N-(4-methylbenzyl) benzenesulfonyl ethyl carbamate.
Nature:
HS-173 is an organic compound with a colorless to pale yellow liquid in appearance. It has low volatility, solubility and surface tension. This compound is stable at room temperature, but may decompose under high temperature and bright light.
Use:
HS-173 are commonly used as pharmaceutical intermediates, especially in the synthesis of biologically active compounds. It can be used as anti-cancer drugs, specific drug synthesis precursor, and play an important role in the field of drug discovery and research and development.
Preparation Method:
The HS-173 can be prepared by reacting methylbenzylamine with P-Toluenesulfonyl chloride under appropriate reaction conditions.
Safety Information:
There is very little information about the toxicity and danger of HS-173, which may be due to its relatively new commercial use. However, as an organic compound, care should be taken to follow regular laboratory safety procedures when used. When performing the operation, avoid contact with skin and eyes, avoid inhaling its vapor or dust, and ensure that you work in a well-ventilated place. If accidental exposure or ingestion occurs, medical help should be sought immediately.
Nature:
HS-173 is an organic compound with a colorless to pale yellow liquid in appearance. It has low volatility, solubility and surface tension. This compound is stable at room temperature, but may decompose under high temperature and bright light.
Use:
HS-173 are commonly used as pharmaceutical intermediates, especially in the synthesis of biologically active compounds. It can be used as anti-cancer drugs, specific drug synthesis precursor, and play an important role in the field of drug discovery and research and development.
Preparation Method:
The HS-173 can be prepared by reacting methylbenzylamine with P-Toluenesulfonyl chloride under appropriate reaction conditions.
Safety Information:
There is very little information about the toxicity and danger of HS-173, which may be due to its relatively new commercial use. However, as an organic compound, care should be taken to follow regular laboratory safety procedures when used. When performing the operation, avoid contact with skin and eyes, avoid inhaling its vapor or dust, and ensure that you work in a well-ventilated place. If accidental exposure or ingestion occurs, medical help should be sought immediately.
Last Update：2024-04-09 21:54:55
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Spot supply
Product Name: HS-173 Visit Supplier Webpage Request for quotationCAS: 1276110-06-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: HS-173 Visit Supplier Webpage Request for quotationCAS: 1276110-06-5
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: HS-173 Visit Supplier Webpage Request for quotationCAS: 1276110-06-5
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: HS-173 Visit Supplier Webpage Request for quotation
CAS: 1276110-06-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1276110-06-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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