Molecular Formula | C27H42O4 |
Molar Mass | 430.63 |
Density | 1.18 |
Melting Point | 198-202℃ |
Boling Point | 563.1±50.0 °C(Predicted) |
Specific Rotation(α) | (c, 1 in CHCl3)-118 |
Solubility | Soluble in methanol |
Appearance | White crystal |
Color | White |
pKa | 14.56±0.70(Predicted) |
Storage Condition | -20°C Freezer |
MDL | MFCD00210550 |
Physical and Chemical Properties | White crystals, soluble in methanol, derived from pseudoopogon, Ophiopogon japonicus. |
Safety Description | 24/25 - Avoid contact with skin and eyes. |
HS Code | 29389090 |
Reference Show more | 1. Zhang Meng, Zhang Xiaodan, Ling Xiaodong, etc. Optimization of co-extraction process of Ophiopogon japonicus, Hawthorn and licorice by Central composite design-response surface methodology [J]. Food industry, 2020, v.41;No.284(05):22-25. |
effect | ruosapogenin has significant anti-inflammatory effect, one of the mechanisms by which ruosaponin exerts anti-inflammatory effects may be by interfering with the protein kinase C signaling pathway and thereby blocking the migration of lymphocytes into the extracellular matrix. |
Use | ruosapengenin has anti-tumor effects, studies have found that ruosaponin extracted from Ophiopogon japonicus has cytotoxic effect on Hela and SMMC-7721 cells, and can play an anti-tumor effect. ruosapogenin has anti-inflammatory, reducing capillary permeability, regulating prostate dysfunction, inhibiting G bacteria and anti-elastase, anti-cerebral ischemia, cerebral hypoxia effect. for content determination/identification/pharmacological experiments. Pharmacological effects: a significant anti-inflammatory, reduce capillary permeability, regulation of prostate dysfunction, inhibition of G bacteria and anti-elastase and other effects. |
biological activity | Ruscogenin is an important steroidal sapogenin extracted from Ophiopogon japonicus, by inhibiting TXNIP/NLRP3 inflammatory body activation and MAPK pathway, it can reduce the blood brain barrier dysfunction induced by cerebral ischemia, and has significant anti-inflammatory and antithrombotic activity. |