Histone Lysine Demethylase Inhibitor VII, GSK-J1
GSK-J1
CAS: 1373422-53-7
Molecular Formula: C22H23N5O2
Histone Lysine Demethylase Inhibitor VII, GSK-J1 - Names and Identifiers
| Name | GSK-J1 |
| Synonyms | GSK J1 GSK-J1 GCK J1 Histone Lysine Demethylase Inhibitor VII, GSK-J1 N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine 3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoic acid |
| CAS | 1373422-53-7 |
| EINECS | 200-258-5 |
| InChIKey | AVZCPICCWKMZDT-UHFFFAOYSA-N |
Histone Lysine Demethylase Inhibitor VII, GSK-J1 - Physico-chemical Properties
| Molecular Formula | C22H23N5O2 |
| Molar Mass | 389.45 |
| Density | 1.292±0.06 g/cm3(Predicted) |
| Boling Point | 608.9±55.0 °C(Predicted) |
| Solubility | DMSO: ≥ 33 mg/mL |
| Appearance | powder |
| Color | white to beige |
| pKa | 4.20±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase? as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| In vitro study | GSK-J1 is selective for H3K27 demethylases of the KDM6 subfamily and specifically binds to endogenous JMJD3. GSK-J1 inhibits TNF-α production by human primary macrophages in an H3K27-dependent manner. GSK-J1 inhibits the demethylase activity of KDM5C with 8.5-fold increased potency compared with that of KDM5B at 1 mM α-ketoglutarate, with IC 50 of 11 μM and 94 μM, respectively. |
Histone Lysine Demethylase Inhibitor VII, GSK-J1 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
Histone Lysine Demethylase Inhibitor VII, GSK-J1 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.568 ml | 12.839 ml | 25.677 ml |
| 5 mM | 0.514 ml | 2.568 ml | 5.135 ml |
| 10 mM | 0.257 ml | 1.284 ml | 2.568 ml |
| 5 mM | 0.051 ml | 0.257 ml | 0.514 ml |
Last Update：2024-01-02 23:10:35
Histone Lysine Demethylase Inhibitor VII, GSK-J1 - Reference Information
| biological activity | GSK-J1 is an inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, and the IC50 value for KDM6B is 60 nM. |
| target | IC50: 60 nM (KDM6B) |
| in vitro study | GSK-J1 is selective for H3K27 demethylases of the KDM6 subfamily and specifically binds to endogenous JMJD3. GSK-J1 inhibits TNF-α production by human primary macrophages in an H3K27-dependent manner. GSK-J1 inhibits the demethylase activity of KDM5C with 8.5-fold increased potency compared with that of KDM5B at 1 mM α-ketoglutarate, with IC 50 of 11 μM and 94 μM, respectively. |
Last Update：2024-04-09 20:52:54
Supplier List
Spot supply
Product Name: GSK-J1 Visit Supplier Webpage Request for quotationCAS: 1373422-53-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: GSK-J1 Visit Supplier Webpage Request for quotationCAS: 1373422-53-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History