Hydroxymethylpropylcellulose
Hydroxy Propyl Methyl Cellulose
CAS: 9004-65-3
Molecular Formula: C3H7O*
Hydroxymethylpropylcellulose - Names and Identifiers
Hydroxymethylpropylcellulose - Physico-chemical Properties
| Molecular Formula | C3H7O* |
| Molar Mass | 59.08708 |
| Density | 1.39 |
| Melting Point | 225-230 °C |
| Boling Point | 1101.5°C at 760 mmHg |
| Flash Point | 619.9°C |
| Water Solubility | SOLUBLE |
| Solubility | H2O: 50mg/mL, clear to very faintly turbid, faintly yellow |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White-like powder |
| Color | White to cream |
| Odor | Odorless |
| Merck | 14,4842 |
| Storage Condition | room temp |
| Stability | Stable. Solid is combustible, incompatible with strong oxidizing agents. |
| MDL | MFCD00131360 |
| Physical and Chemical Properties | Density 1.39 water-SOLUBLE SOLUBLE |
| Use | Used as a synthetic resin dispersant, coating molding agent, can also be used as a thickening agent |
Hydroxymethylpropylcellulose - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 1 |
| RTECS | NF9125000 |
| FLUKA BRAND F CODES | 3-10 |
| TSCA | Yes |
| HS Code | 39129000 |
Hydroxymethylpropylcellulose - Reference
| Reference Show more | 1. Zhang Yongping, Xu Jian, Xie Weijie. Optimization of matrix formulation and molding process of indomethacin hydrophilic gel patch by Central composite design-response surface methodology [J]. Medical Review, 2018, 037(005):593-599. 2. Xie Weijie, Zhang Yongping, Xu Jian. Screening Matrix formulation of indomethacin hydrophilic gel patch by uniform design [J]. China Pharmacy, 2017(10). 3. See in the water, Li Yueming, Li Dan, zynina, Zhang zonsen, Xu Jianchun, Xu binzheng. Study on the preparation technology of egg yolk wine [J]. Journal of fermentation science and technology, 2021,50(01):50-52 62. 4. Xie H, Li L, Sun Y, Wang Y, Gao S, Tian Y, Ma X, Guo C, Bo F, Zhang L. An Available Strategy for Nasal Brain Transport of Nanocomposite Based on PAMAM Dendrimers via In Situ Gel. Nanomaterials. 2019; 9(2):147. https://doi.org/10.3390/nano9020147 5. Zhou, Qiuna, et al. "Baicalein and hydroxypropyl-γ-cyclodextrin complex in poloxamer thermal sensitive hydrogel for vaginal administration." International journal of pharmaceutics 454.1 (2013): 125-134.https://doi.org/10.1016/j.ijpharm.2013.07.006 6. Jiang, Yingchun, et al. "Modified chitosan thermosensitive hydrogel enables sustained and efficient anti-tumor therapy via intratumoral injection." Carbohydrate polymers 144 (2016): 245-253.https://doi.org/10.1016/j.carbpol.2016.02.059 7. [IF=5.875] Qiuna Zhou et al."Baicalein and hydroxypropyl-γ-cyclodextrin complex in poloxamer thermal sensitive hydrogel for vaginal administration."Int J Pharmaceut. 2013 Sep;454:125 8. [IF=11.301] Xue Gao et al."Electric power generation using paper materials."J Mater Chem A. 2019 Sep;7(36):20574-20578 9. [IF=5.455] Dou Yinghuan et al."Preparation, optimization and in vitro-in vivo evaluation of Shunxin sustained release granules."Chin Med-Uk. 2019 Dec;14(1):1-10 10. [IF=4.952] Xuan Zhou et al."Hydroxypropyl methylcellulose (HPMC) reduces the hardening of fructose-containing and maltitol-containing high-protein nutrition bars during storage."LWT-FOOD SCIENCE AND TECHNOLOGY. 2022 Jun;163:113607 |
Hydroxymethylpropylcellulose - Nature
Open Data Verified Data
It is an important species in non-ionic cellulose Mixed ethers. Odorless, tasteless, non-toxic, the product is white powder or loose fiber, particle size through 80 mesh sieve. It does not react with heavy metals. The ratio of methoxy content and hydroxypropyl content in the finished product is different, and the viscosity is different. HPMC is actually a kind of methyl cellulose modified by epoxy methane (methyl Oxy propylene), so it has the characteristics of methyl cellulose similar to cold water soluble, hot water insoluble, solubility in organic solvents is better than water-soluble, it is soluble in anhydrous methanol and ethanol, but also soluble in chlorinated hydrocarbons such as dichloromethane, trichloroethane and acetone, isopropanol, diacetone alcohol and other organic solvents.
Last Update：2024-01-02 23:10:35
Hydroxymethylpropylcellulose - Preparation Method
Open Data Verified Data
There are two types of industrial preparation of HPMC: batch and continuous. The batch type is an etherification reaction with an etherifying agent in an autoclave after alkaline treatment of cellulose, pressing, pulverization and ripening to produce a crude product. The continuous type does not need to carry out pressing, crushing and ripening, and is easy to carry out etherification reaction in the high pressure pipeline reactor after alkalization, and continuously feeds and feeds. The preparation of HPMC mostly adopts the liquid phase method, because the uniformity of the finished product obtained by this method is good. In general, 35% to 50% alkali liquor is used for preparing alkali cellulose, and the mass ratio of cellulose to alkali liquor is 1 :( 0.5 to 2.6).
Last Update：2022-01-01 11:08:34
Hydroxymethylpropylcellulose - Standard
Authoritative Data Verified Data
- This product is 2-hydroxypropyl ether methyl cellulose, which is a semi-synthetic product and can be manufactured by two methods:(1) after the cotton wool or wood pulp fiber is treated with caustic soda, then it reacts with methyl chloride and propylene oxide successively, and is refined and pulverized;(2) it is treated with sodium hydroxide with methyl cellulose of appropriate grade, and propylene oxide at high temperature and high pressure reaction to the desired extent, refined. The molecular weight ranges from 10 000 to 1 500 000.
- Hypromellose is classified into four substitution types, namely, 1828, 2208, 2906, and 2910 types, depending on the content of the methoxy group and the hydroxypropoxy group.
Last Update：2024-01-02 23:10:35
Hydroxymethylpropylcellulose - Trait
Authoritative Data Verified Data
- This product is white or off-white fibrous or granular powder; Odorless
- This product is almost insoluble in anhydrous ethanol, ether or acetone. I swell into a clear or slightly turbid colloidal solution in cold water.
Last Update：2022-01-01 11:25:23
Hydroxymethylpropylcellulose - Introduction
Soluble in water, insoluble in hot water, soluble in DMF, DMSO, hot ethylene glycol and pyridine, insoluble in absolute ethanol, diethyl ether and chloroform. The aqueous solution is surface active. After drying, it forms a thin film. After heating and cooling, it undergoes a reversible transition from sol to gel.
Last Update：2022-10-16 17:29:51
Hydroxymethylpropylcellulose - Use
Open Data Verified Data
in the polymerization of synthetic resin, HPMC can be used as dispersant and suspending agent for the polymerization of vinyl chloride and its copolymer; Emulsifier for the copolymerization of dichloroethylene-vinyl acetate; Suspension stabilizer for the copolymerization of vinyl acetate and vinyl chloride; stabilizers for graft copolymerization of butadiene, acrylonitrile and styrene. In the pharmaceutical and food industry as an additive, thickening, solid, film-forming, dispersion, stability and other effects, but also moisture, mold, to maintain moisture and other effects. In the coating industry can be used as emulsifier, thickener, film forming agent and stabilizer, in the photosensitive printing board, mainly using its film forming property and photo degradability, it can be quickly developed with water. As a detergent, it can improve the stain resistance of fabrics.
Last Update：2022-01-01 11:08:34
Hydroxymethylpropylcellulose - Differential diagnosis
Authoritative Data Verified Data
- take l g of this product, heat water (80~90°C) l0 0 m l, stir to form a slurry, cool in an ice bath to form a viscous liquid; take 2M l into the test tube, slowly add 0.035% anthrone sulfuric acid solution lm l along the tube wall, place it for 5 minutes, and show a blue-green ring at the interface between the two liquids.
- an appropriate amount of the viscous liquid under identification (1) was poured onto a glass plate, and upon evaporation of moisture, a thin film having toughness was formed.
- take 0.5g of this product, evenly disperse in 50ml boiling water, and use electromagnetic stirring to form insoluble slurry; Under electromagnetic stirring, cool the slurry to 1CTC, A clear or slightly turbid solution is formed, 50ml of water is added, electromagnetic stirring and simultaneous heating, the temperature is raised at a rate of 2-5X per minute, and the flocculation temperature for producing turbidity should not be less than 50°C.
Last Update：2022-01-01 11:25:24
Hydroxymethylpropylcellulose - Safety
Open Data Verified Data
This product is non-toxic. The finished product is packed in Kraft three-in-one composite bags, lined with polyethylene film bags, each 25kg, or packaged according to user requirements. Store in a dry, ventilated, clean warehouse, away from heat, avoid direct sunlight. Transportation should be protected from the sun and rain.
Last Update：2022-01-01 11:08:35
Hydroxymethylpropylcellulose - Exam
Authoritative Data Verified Data
viscosity
- The indicated viscosity is less than 600mPa • s, according to Method 1, viscosity® is 80% ~ 120% of the indicated viscosity; The indicated viscosity is greater than or equal to 600mPa * s, according to Method 2, the viscosity shall be 75% to 140% of the indicated viscosity.
- take an appropriate amount of this product (calculated according to the dry product) and add 90 x: water to make 2 .0 %C g/g) of the solution, fully stirred for about 10 minutes, until the particles are completely uniformly dispersed and wet, and there are no undissolved sample particles in the inner wall of the bottle, during cooling, agitation was continued to remove air bubbles and, if necessary, the weight was adjusted with cold water to remove all foam as a test solution.
- Method 1: At 20 t ± 0 . l C, according to the outflow time of not less than 200 seconds, the kinematic viscosity (v) of the solution is measured by using the appropriate internal diameter of the Ubbelohde viscometer, and the density (P) of the solution is measured under the same conditions.
- Method 2: At 20T ± 0. r c, select the appropriate single column type rotational viscometer (Brookfield type LV model or equivalent viscometer) to measure the following conditions (General 0633 third method), rotate 2 minutes after reading, stop 2 minutes, the experiment was repeated 2 more times, and the average of three experiments was taken.
pH
take this product l.O g (based on dry product), add 90 ml of water into 50 ml of water while stirring, cool, add water to make the solution into 10 ml of water, and stir until the solution is completely dissolved, measured according to law (General rule 063 1 ),p H value should be 5.0~8 .0.
insoluble in water
take this product l .O g, put in a beaker, heat water (80 ~ 90X :) 100ml to swell for about 15 minutes, then cool in an ice bath, add 300ml of water (the test sample with high viscosity can increase the volume of water appropriately to ensure the filtration of the solution), stir well, and filter with No. 1 vertical melting glass Crucible dried at 105°C to constant weight, the Beaker was washed with water, washed with water and placed in the above vertical melting glass crucible, filtered, and dried at 105C to constant weight. The remaining residue should not exceed 5mg(0.5%).
loss on drying
take this product, in 105C drying for 2 hours, loss of weight shall not exceed 0831 (General Principles).
ignition residue
The l.O g of this product shall be taken for inspection according to law (General rule 0841), and the residue shall not exceed 1 .5%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).
arsenic salt
take this product l.O g, add calcium hydroxide l.O g, mix, add water and stir evenly, after drying, first burn with small fire to charring, then burn at 600C to Ash completely, cool, add hydrochloric acid 5M l and water 23tnl to dissolve, inspection according to law (General Principles 0822 first law), shall comply with the provisions (0.0002%).
Last Update：2022-01-01 11:25:25
Hydroxymethylpropylcellulose - Molding Process
Open Data Verified Data
The solution is uniformly coated on the platform, and after drying, a film product can be prepared, which is transparent and flexible.
Last Update：2022-01-01 11:08:35
Hydroxymethylpropylcellulose - Content determination
Authoritative Data Verified Data
methyl chloride
take this product, according to methoxy, ethoxy, hydroxypropoxy determination method (General 0712) determination. If the second method (capacity method) is used, take this product, precision weighing, determination according to law, the measured amount of methoxyl group (%) minus hydroxypropoxyl group (%) and (31/75x 0. 9 3) the product, that is, get.
hydroxypropyl chloride
take this product, according to the methoxy, ethoxy, hydroxypropoxy determination method (General 0712), if the second method (Volumetric method), take this product 0. l g, precision weighing, determination according to law, that is.
Last Update：2022-01-01 11:25:26
Hydroxymethylpropylcellulose - Category
Authoritative Data Verified Data
pharmaceutical excipients, release blockers and coating materials.
Last Update：2022-01-01 11:25:26
Hydroxymethylpropylcellulose - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:25:26
Hydroxymethylpropylcellulose - Marking
Authoritative Data Verified Data
The substitution type is indicated, and the viscosity is indicated in m P a * S.
Last Update：2022-01-01 11:25:27
Hydroxymethylpropylcellulose - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | hydroxypropyl methylcellulose is a propylene glycol ether of methylcellulose, the hydroxypropyl group and the methyl group are both combined with the anhydrous glucose ring of cellulose by ether bond, and are white to off-white cellulose powder or granules, which have the characteristics of cold water dissolution and hot water insolubility similar to methyl cellulose. Solubility in organic solvents is better than water-soluble, soluble in anhydrous methanol and ethanol solution, but also soluble in chlorinated hydrocarbons and ketones and other organic solvents. Soluble in water, its aqueous solution has surface activity, and after drying, it forms a thin film, which undergoes a reversible transition from Sol to gel by heating and cooling. In the cold drink can be used alone, can also be used with other emulsifiers, stabilizers, the largest amount of cold drink 1%. In recent years, it has been widely used in petrochemical industry, paper making, leather, textile printing and dyeing, medicine, food, cosmetics and other industries as dispersants, thickeners, adhesives, excipients, capsules, oil resistant coatings and fillers. FIG. 1 shows the molecular structure of hydroxypropyl methylcellulose. |
| Usage | Usage: thickener, emulsifier, stabilizer. 1. Note: Hydroxypropyl Methyl Cellulose has a variety of excellent properties, can be used for baking food, paste food, nutritional food, milk stir beverage, pie, filling, salad decorative ingredients and fast food. The use of its thermal gel properties to produce fried food, not only can save a lot of frying oil, and the product has a unique taste of soft inside and outside; The use of its acid, alkali stability, anti-enzyme, not involved in metabolism, enhance the characteristics of gastrointestinal motility, can also be used to manufacture a variety of health food. 2. Use range and usage amount (1) China's "health standards for the use of food additives" (GB 2760-1996) provides: can be used in all kinds of food according to the production needs. (2) the actual use of reference: the use of this product film and the film of high light transmittance, can be used to manufacture protein casing, the amount of 5%; Used as mayonnaise thickener (HPMC-60RT400), the dosage is 0.5% ~ 2%. |
| ophthalmic drugs | 【medicinal properties and application】 it can promote corneal moisture by stabilizing and thickening the tear film in front of the cornea, it can prolong the cutting time of tear film and prolong the retention time of tear film in dry eyes. Clinical for the lack of tears caused by eye dryness and eye irritation, for the treatment of keratoconjunctivitis sicca, exposure keratitis and neuroparalytic keratitis, to prevent corneal injury; Can be used for hard contact lenses or artificial eye lubricant; it is used for gonioscopy and as a medium to protect the cornea during retinal laser photocoagulation, laser mental plasty or iridectomy when contact lens examination is required. [dosage] eye drops: 0.3% ~ 1% solution, 1 drop, 3~4 times/d. 2% solution of this product was used for Gonioscopy. [attention and contraindication] Sometimes there may be blurred vision or palpebral adhesion. The duration of continuous dripping should not exceed 3d. Wearing soft contact lens is contraindicated in patients with corneal epithelial disease. The lens should be prevented from floating when wearing hard contact lenses. [specification] hydroxypropyl methyl cellulose eye drops: 0.3%,0.5%,1.0%,2.5%. This information was edited by chemical book Xiaonan (2015-08-31). |
| identification test | solubility may swell in water to form a clear Milky viscous colloidal solution. Insoluble in ethanol. 2, 3 and 4. Are the same as those for "hydroxypropyl cellulose (10012). |
| toxicity | ADI is not specified (FAO/WHO,2001). Safe for use in food (FDA.§ 172.874,2000). Ld505200 mg/kg (rat, intraperitoneal injection). |
| usage limit | FAO/WHO(1984): Cold drink 10g/kg (based on the final product, used alone or in combination with other emulsifiers, stabilizers and thickeners). GB 2760-96: all kinds of food, GMP is the limit. |
| Use | thickening agent; Stabilizer; Emulsifier; Gelling agent; Suspending agent. used as a synthetic resin dispersant, coating molding agent, can also be used as a thickener This product is used in the textile industry as a thickener, dispersant, binder, emulsifier and stabilizer. Also widely used in synthetic resin, petrochemical, ceramics, paper, leather, medicine, food, cosmetics and other industries. used in synthetic resin, petrochemical industry, ceramics, paper making, leather, textile printing and dyeing, medicine, food, cosmetics and other daily chemicals, as dispersant, thickener, binder, excipient, capsule, oil-resistant coatings and fillers, etc. |
| production method | The refined cotton cellulose was treated with alkali solution at 35-40 ° C. For half an hour, and the cellulose was crushed by pressing, the aging is suitably carried out at 35 ° C. So that the obtained average degree of polymerization of the alkali fiber is in the desired range. The alkali fiber is put into the etherification kettle, propylene oxide and methyl chloride are sequentially added, and the etherification is carried out at 50-80 ° C. For 5h, and the maximum pressure is about 1.8MPa. The reaction product was worked up (neutralization with hydrochloric acid, iron removal with oxalic acid, washing, drying). Raw material consumption quota cotton pulp 1100kg/t, methyl chloride and propylene oxide 4300kg/t, Solid alkali 1200kg/t, hydrochloric acid 30kg/t, oxalic acid 50kg/t. 100 of the refined short cotton wool was immersed in a 45% alkali solution at a temperature of 35 to 40 ° C. For 0.5 to 1.0 h, and then taken out and pressed. Pressure was stopped when the weight was 2.7 times the weight of cotton wool. Crushing and loosening were performed. Aging at 35 C for 16 h. Put the aged alkali fiber into the reaction kettle, add methyl chloride and propylene oxide in turn, and react for 5~8 h at 80 ℃ and 1.8 MPa, then, hydrochloric acid and oxalic acid were added to hot water at 90 ° C. To wash the material to enlarge the volume. Dehydrate with a centrifuge. Washing was carried out to neutrality and when the water content in the material was less than 60%, drying was carried out in a stream of hot air at 130 °c until the water content was less than 5%. The final product was crushed through a 20-mesh screen. prepared from cellulose, methyl chloride and ethylene oxide. |
Last Update：2024-04-09 21:32:09
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