Hydroxynicotinicacidmethylester

Hydroxynicotinicacidmethylester - Names and Identifiers

Name	Hydroxynicotinicacidmethylester
Synonyms	Methyl 5-hydroxynicotinate METHYL 5-HYDROXYNICOTINATE Hydroxynicotinicacidmethylester 5-HYDROXYNICOTINIC ACID METHYL ESTER 5-Hydroxynicotinic acid methyl ester methyl 5-hydroxypyridine-3-carboxylate METHYL 5-HYDROXY-3-PYRIDINECARBOXYLATE Methyl 5-hydroxynicotinate methy ester Methyl 5-hydroxypyridine-3-carboxylate 5-HYDROXY-3-PYRIDINECARBOXYLIC ACID METHYL ESTER
CAS	30766-22-4
InChI	InChI=1/C7H7NO3/c1-11-7(10)5-2-6(9)4-8-3-5/h2-4,9H,1H3

Hydroxynicotinicacidmethylester - Physico-chemical Properties

Molecular Formula	C7H7NO3
Molar Mass	153.14
Density	1.287±0.06 g/cm3(Predicted)
Melting Point	190 °C
Boling Point	374.2±22.0 °C(Predicted)
Flash Point	180.1°C
Solubility	DMSO (Heated, Sonicated), Methanol (Slightly, Sonicated)
Vapor Presure	3.95E-06mmHg at 25°C
Appearance	Pale beige powder and caking
Color	Light beige
pKa	8.44±0.10(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.551
MDL	MFCD00191521

Hydroxynicotinicacidmethylester - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S39 - Wear eye / face protection. S37/39 - Wear suitable gloves and eye/face protection
WGK Germany	3
HS Code	29333990
Hazard Note	Irritant/Keep Cold

Hydroxynicotinicacidmethylester - Introduction

Nature:
is a white crystalline solid with a distinctive odor. It is soluble in water, alcohol and ether at room temperature, and insoluble in Ketone solvents.

Use:
It is often used as a pharmaceutical intermediate. It can be used to synthesize some compounds with pharmacological activity, especially some drugs with anti-tumor, anti-virus and anti-inflammatory activity. In addition, calcium can also be used as nutritional supplements and food additives.

Method:
A commonly used method of preparation is obtained by esterification of hydroxynicotinic acid. The specific preparation method is as follows:
First, hydroxynicotinic acid acetate reacts with methanol, and under acidic conditions, it is generated by dehydration reaction. Then, through crystallization and purification steps, the pure calcium is obtained.

Safety Information:
Regarding the safety information, there are no reports of particularly serious toxicity. However, as a chemical substance, it is still necessary to pay attention to safe operation and avoid contact with eyes, skin and inhaled substances. Before use, you can refer to the relevant safety technical instructions and follow the laboratory and industry safety practices. In case of accidental contact, rinse immediately with plenty of water and consult your doctor's advice.

Last Update：2024-04-09 21:54:55