Hydroxyprogesterone
17A-hydroxyprogesterone
CAS: 68-96-2
Molecular Formula: C21H30O3
Hydroxyprogesterone - Names and Identifiers
| Name | 17A-hydroxyprogesterone |
| Synonyms | prodix prodox gestagenogador Hydroxyprogesterone 17a-Hydroxyprogesterone 17A-hydroxyprogesterone 17alpha-Hydroxyprogesterone 4-Pregnen-17a-ol-3,20-dione 17-Alpha-Hydroxy-Progesterone 17-Hydroxypregn-4-en-3,20-dione 17-hydroxy-pregn-4-ene-20-dione 17-hydroxypregn-4-ene-3,20-dione 17a-Hydroxypregn-4-ene-3,20-dione 17-alpha-hydroxypregn-4-ene-3,20-dione delta(4)-pregnene-17alpha-ol-3,20-dione (8R,9S,10R,13S,14S,17R)-17-ACETYL-17-HYDROXY-10,13-DIMETHYL-1,2,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE |
| CAS | 68-96-2 |
| EINECS | 200-699-4 |
| InChI | InChI=1/C21H30O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h12,16-18,24H,4-11H2,1-3H3 |
Hydroxyprogesterone - Physico-chemical Properties
| Molecular Formula | C21H30O3 |
| Molar Mass | 330.46 |
| Density | 1.0998 (rough estimate) |
| Melting Point | 276°C |
| Boling Point | 407.89°C (rough estimate) |
| Flash Point | 9℃ |
| Water Solubility | 5.056mg/L(20 ºC) |
| Solubility | soluble in Chloroform |
| Vapor Presure | 2.37E-11mmHg at 25°C |
| Appearance | neat |
| Color | White to Almost white |
| Merck | 14,4839 |
| BRN | 3218109 |
| pKa | 13.03±0.60(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 90 ° (C=1, CHCl3) |
| Physical and Chemical Properties | Crystals (acetone/hexane). Melting Point 221 °c (219-220 °c). [Α] 20/D 97 ° (chloroform). |
| Use | Used as a steroid hormone drug Intermediate |
| In vitro study | 17α-OHP is a progesterone receptor agonist similar to progesterone, although less effective. It is also a chemical intermediate in the biosynthesis of steroid hormones such as androgens, estrogenic sex hormones, glucocorticoids, and mineralocorticoids. |
| In vivo study | 17-Hydroxyprogesterone is a potent steroid inducer of GVBD (germ bleb rupture). |
Hydroxyprogesterone - Risk and Safety
| Risk Codes | R61 - May cause harm to the unborn child R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S22 - Do not breathe dust. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. |
| UN IDs | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS | TU5060000 |
| HS Code | 38220090 |
Hydroxyprogesterone - Reference
| Reference Show more | 1. [IF=7.514] Suo Decheng et al."Trace analysis of progesterone and 21 progestins in milk by ultra-performance liquid chromatography coupled with high-field quadrupole-orbitrap high-resolution mass spectrometry."Food Chem. 2021 Nov;361:130115 |
Hydroxyprogesterone - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| Introduction | 17 α-hydroxyprogesterone, sometimes referred to as hydroxyprogesterone (English: hydroxyprogestin, OHP) is a kind of progesterone-like endogenous progesterone steroid hormone, but also many endogenous steroid hormone biosynthesis precursors, including androgen, estrogen, glucocorticoids and mineralocorticoids and some neurosteroids. |
| biological activity | 17-hydroxyprogestogen (17-OHP) is an endogenous progestogen that is a chemical intermediate in the biosynthesis of other steroid hormones. |
| Use | intermediates of hydrocortisone, megestrol, progesterone caproate. as a steroid hormone drug intermediate A long-acting progestogen |
| production method | can be used to open the ring, acetylation, oxidation, hydrolysis, epoxidation, oxidation, addition, it is prepared by catalytic hydrogenation and other steps. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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