IDE-1
IDE1
CAS: 1160927-48-9
Molecular Formula: C15H18N2O5
IDE-1 - Names and Identifiers
IDE-1 - Physico-chemical Properties
| Molecular Formula | C15H18N2O5 |
| Molar Mass | 306.31 |
| Solubility | DMSO: ≥ 30 mg/mL |
| Appearance | White solid. |
| Storage Condition | -20℃ |
| In vitro study | IDE1 enhances the definitive endoderm (DE) differentiation of human-induced pluripotent stem cells (hiPSCs) with Activin A/Wnt3a being significantly more potent in both 2D and 3D cultures compared to IDE1. IDE1 could efficiently induces DE differentiation through various protocols in vitro. Treatment of the hiPSCs-derived EBs with IDE-1 shows minor increase (p<0.01) of DE-markers cells compared to Activin A/Wnt3a treatment. IDE1 possess several advantages over other inducing factors including high permeability, influence, diversity, low cost, and easy to use and for the first time, Melton’s team showed that Activin A can be substituted by two cell-permeable small molecules, IDE1 and IDE2. IDE1 could induce phosphorylation of Smad2 after incubation for 24 h or more at levels comparable to those induced by Activin A treatment. Treatment of hiPSCs with IDE1 (2 mM) also leads to endodermal differentiation but with a significantly lower efficiency than Activin A/Wnt3a. |
IDE-1 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.265 ml | 16.323 ml | 32.646 ml |
| 5 mM | 0.653 ml | 3.265 ml | 6.529 ml |
| 10 mM | 0.326 ml | 1.632 ml | 3.265 ml |
| 5 mM | 0.065 ml | 0.326 ml | 0.653 ml |
Last Update：2024-01-02 23:10:35
IDE-1 - Reference Information
| biological activity | IDE1 is a kind of fixed endoderm inducer, which may be used in organ transplantation and other aspects. |
| in vitro study | IDE1 enhances the definitive endoderm (DE) differentiation of human-induced pluripotent stem cells (hipSCs) with Activin A/Wnt3a being significantly more potent in both 2D and 3D cultures compared to IDE1. IDE1 could efficiently induces DE differentiation through various protocols in Vitro. Treatment of the hiPSCs-derived EBs with IDE-1 shows minor increase (p<0.01) of DE-markers cells compared to Activin A/Wnt3a treatment. IDE1 possess several advantages over other inducing factors including high permeability, influence, diversity, low cost, and easy to use and for the first time, melton's team show that Activin a can be substituted by two cell-permeable small molecules, IDE1 and IDE2. IDE1 could induce phosphorylation of Smad2 after incubation for 24 h or more at levels comparable to those induced by Activin a treatment. Treatment of hipSCs with IDE1 (2 mM) also led to endodermal differentiation but with a significantly lower efficiency than Activin A/Wnt3a. |
Last Update：2024-04-09 02:00:02
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CAS: 1160927-48-9
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CAS: 1160927-48-9
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Product Name: IDE1 Visit Supplier Webpage Request for quotation
CAS: 1160927-48-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1160927-48-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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