INCB
INCB-057643 ；incb057643
CAS: 1820889-23-3
Molecular Formula: C20H21N3O5S
INCB - Names and Identifiers
INCB - Physico-chemical Properties
| Molecular Formula | C20H21N3O5S |
| Molar Mass | 415.46 |
| Density | 1.370±0.06 g/cm3(Predicted) |
| Boling Point | 787.7±60.0 °C(Predicted) |
| Solubility | DMSO : 62.5 mg/mL (150.44 mM; Need ultrasonic) |
| pKa | 14.74±0.40(Predicted) |
| Storage Condition | -20°C |
| In vitro study | At low concentrations (nM),INCB057643 inhibited binding of BRD2/BRD3/BRD4 to acetylated histone H4 with selectivity. In in vitro experiments, INCB057643 inhibits proliferation of human AML, DLBCL and multiple myeloma cell lines with reduced levels of MYC protein. Treatment of cells with INCB057643 for 48 hours induced G1 phase arrest and a concentration-dependent increase in apoptosis. In human and mouse whole blood cells, INCB057643 inhibited LPS-stimulated production of cytokines, including IL-6, IL-10 and MIP-1α. INCB057643 inhibits the proliferation of prostate cancer cells. In the short-term cell proliferation assay, INCB057643 was more effective on androgen-dependent cells (VCaP and LNCaP) than on non-androgen-dependent cells (DU145 and PC3). |
| In vivo study | In AML, DLBCL and myeloma transplantation models, oral INCB057643 caused significant anti-tumor effects. In the mouse model inoculated with 22Rv1 tumor cells, 3 mg/kg significantly inhibited tumor growth (T/C%:45%) and sustained reduction in tumor weight. |
INCB - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.407 ml | 12.035 ml | 24.07 ml |
| 5 mM | 0.481 ml | 2.407 ml | 4.814 ml |
| 10 mM | 0.241 ml | 1.203 ml | 2.407 ml |
| 5 mM | 0.048 ml | 0.241 ml | 0.481 ml |
Last Update：2024-01-02 23:10:35
INCB - Introduction
INCB-057643 ;incb057643 is a chemical substance with the following properties:
1. Appearance: INCB-057643 ;incb057643 is a colorless or light yellow liquid.
2. Safety: INCB-057643 ;incb057643 is generally considered to be low-toxic, but it still needs to be used carefully. Contact with skin or eyes should be washed immediately with water, and timely consult a doctor. When using or handling INCB-057643 ;incb057643, follow relevant safety practices and wear appropriate protective equipment, such as protective glasses and gloves.
INCB-057643 ;incb057643 is mainly used in the following fields:
1. Electronics industry: INCB-057643 ;incb057643 can be used as a coating and packaging material for semiconductor materials.
2. Optical industry: Due to its high refractive index and transparency, INCB-057643 ;incb057643 can be used to prepare optical lenses and lenses.
3. Surface coating: INCB-057643 ;incb057643 can be used for coatings in the fields of automobiles, construction and aerospace to provide wear-resistant, anti-corrosion and waterproof effects.
1. Appearance: INCB-057643 ;incb057643 is a colorless or light yellow liquid.
2. Safety: INCB-057643 ;incb057643 is generally considered to be low-toxic, but it still needs to be used carefully. Contact with skin or eyes should be washed immediately with water, and timely consult a doctor. When using or handling INCB-057643 ;incb057643, follow relevant safety practices and wear appropriate protective equipment, such as protective glasses and gloves.
INCB-057643 ;incb057643 is mainly used in the following fields:
1. Electronics industry: INCB-057643 ;incb057643 can be used as a coating and packaging material for semiconductor materials.
2. Optical industry: Due to its high refractive index and transparency, INCB-057643 ;incb057643 can be used to prepare optical lenses and lenses.
3. Surface coating: INCB-057643 ;incb057643 can be used for coatings in the fields of automobiles, construction and aerospace to provide wear-resistant, anti-corrosion and waterproof effects.
Last Update：2024-04-09 21:04:16
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Product Name: INCB-057643 ；incb057643 Visit Supplier Webpage Request for quotation
CAS: 1820889-23-3
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CAS: 1820889-23-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: INCB-057643 ；incb057643 Visit Supplier Webpage Request for quotation
CAS: 1820889-23-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1820889-23-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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