INCB024360
INCB024360
CAS: 914471-09-3
Molecular Formula: C9H7ClFN5O2
INCB024360 - Names and Identifiers
INCB024360 - Physico-chemical Properties
| Molecular Formula | C9H7ClFN5O2 |
| Molar Mass | 271.64 |
| Density | 1.78±0.1 g/cm3(Predicted) |
| Boling Point | 504.7±60.0 °C(Predicted) |
| Appearance | Solid |
| pKa | 7.54±0.69(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | In HeLa cells, INCB024360 showed high inhibitory activity against IDO1 with an IC50 of 19 nM. In the co-culture system of dendritic cells or tumor cells of human allogeneic lymphocytes, INCB024360, through IDO1 inhibition, reverses IDO-expressed HeLa cells or DCs-mediated T cell inhibition, and increases the differentiation and functional activity of CD4 T cells, CD8 T cells, and NK cells. |
| In vivo study | In mice bearing GM-CSF-secretory B16 tumors, INCB024360 (75 mg/kg B. I. d) caused a dose-dependent inhibition of tumor growth. INCB024360 significantly inhibited tumor growth in immunocompetent mice, but had no inhibitory effect on immunodeficient mice. |
INCB024360 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.681 ml | 18.407 ml | 36.813 ml |
| 5 mM | 0.736 ml | 3.681 ml | 7.363 ml |
| 10 mM | 0.368 ml | 1.841 ml | 3.681 ml |
| 5 mM | 0.074 ml | 0.368 ml | 0.736 ml |
Last Update：2024-01-02 23:10:35
INCB024360 - Reference Information
| biological activity | INCB024360 is a potent, competitive, its IC50 is 67 nM. Phase 2. INCB024360 analog (INCB14943) is a potent competitive inhibitor of IDO1 (indoleamine-(2,3)-dioxygenase) with an IC50 of 67 nM. |
| Target | Value |
| IDO1 (Cell-free assay) | 67 nM |
Last Update：2024-04-09 21:54:55
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Spot supply
Product Name: INCB024360 Visit Supplier Webpage Request for quotationCAS: 914471-09-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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