IOWH-032

Name	IOWH032
Synonyms	CS-950 IOWH032 IOWH032 IOWH-032 IOWH 032 iOWH-032 IOWH 032 3-(3,5-DibroMo-4-hydroxyphenyl)-N-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxaMide 3-(3,5-Dibromo-4-hydroxyphenyl)-N-[(4-phenoxyphenyl)methyl]-1,2,4-oxadiazole-5-carboxamide 1,2,4-Oxadiazole-5-carboxamide, 3-(3,5-dibromo-4-hydroxyphenyl)-N-[(4-phenoxyphenyl)methyl]- 3-(3,5-DIBROMO-4-OXOCYCLOHEXA-2,5-DIEN-1-YLIDENE)-N-[(4-PHENOXYPHENYL)METHYL]-1,2,4-OXADIAZOLE-5-CARBOXAMIDE
CAS	1191252-49-9

Molecular Formula	C22H15Br2N3O4
Molar Mass	545.18
Density	1.670±0.06 g/cm3(Predicted)
Solubility	DMSO 100 mg/mL (183.42 mM); Water <1 mg/mL (<1 mM); Ethanol <1 mg/mL (<1 mM)
pKa	3.34±0.46(Predicted)
Storage Condition	2-8°C
MDL	MFCD25977119
In vitro study	In a cell-related assay T84-CFTR, IOWH032 showed inhibitory activity against CFTR with an IC50 of 6.87 μm. in a cell-related assay T84-CFTR, iow032 showed inhibitory activity against CFTR with an IC50 of 6.87 μm.
In vivo study	IOWH032 produced a statistically significant inhibition of cholera toxin (CTX)-induced secretions in a mouse closed system model. In a rat model in which the cecum was excised, iow032 (5 mg/kg) reduced fecal excretion by-70%. iow032 produced a statistically significant inhibition of cholera toxin (CTX)-induced secretions in a mouse closed system model. In a rat model in which the cecum was excised, iow032 (5 mg/kg) reduced fecal excretion by-70%.

IOWH032 is a synthetic CFTR inhibitor with an IC50 of 1.01 μM in CHO-CFTR cell assays. Phase 2.

Last Update：2022-10-16 17:41:18

biological activity	IOWH032 is a synthetic CFTR inhibitor. in CHO-CFTR cell assay, IC50 is 1.01 μM. Phase 2. IOWH032 is a synthetic CFTR inhibitor. in CHO-CFTR cell assay, IC50 is 1.01 μM. Phase 2.
in vitro study	in T84-CFTR cell-related tests, IOWH032 showed inhibitory activity against CFTR with IC50 of 6.87 μM. in T84-CFTR cell related tests, IOWH032 showed inhibitory activity on CFTR with IC50 of 6.87 μM.
in vivo study	in the mouse closed system model, IOWH032 produced a statistically significant inhibition of secretion induced by cholera toxin (CTX). In a rat model with caecum resection, IOWH032 (5 mg/kg) reduced ~ 70% excreta excretion. in the mouse closed system model, IOWH032 produced a statistically significant inhibition of secretion induced by cholera toxin (CTX). In a rat model with caecum resection, IOWH032 (5 mg/kg) reduced ~ 70% excreta excretion.
target	TargetValue CFTR 1.01 μM
Target	Value
CFTR	1.01 μM

Last Update：2024-04-09 20:52:54

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Product Name: IOWH032 Visit Supplier Webpage Request for quotation
CAS: 1191252-49-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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IOWH-032

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