IPdR
5-Iodo-2-pyrimidinone-2'-deoxyribose
CAS: 93265-81-7
Molecular Formula: C9H11IN2O4
IPdR - Names and Identifiers
| Name | 5-Iodo-2-pyrimidinone-2'-deoxyribose |
| Synonyms | IPdR Ropidoxuridine Idoxuridine Impurity 2 Idoxuridine Deoxy Impurity 5-Iodo-2-pyrimidinone-2'-deoxyribose 1-(2-deoxy-beta-ribofuranosyl)-5-iodo-2-pyrimidinone 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidin-2-one |
| CAS | 93265-81-7 |
IPdR - Physico-chemical Properties
| Molecular Formula | C9H11IN2O4 |
| Molar Mass | 338.1 |
| In vitro study | Ropidoxuridine is an orally bioavailable pro-drug of IUdR (5-iodo-2'-deoxyuridine). Ropidoxuridine demonstrates strong synergy effects with Alisertib at clinically relevant concentrations. |
| In vivo study | In an orthotopic tumor model, Ropidoxuridine (750 mg/kg/day) and Alisertib (30 mg/kg/day) demonstrate strong synergy effects. |
IPdR - References
| biological activity | Ropidoxuridine (IPdR) is a new oral, halogenated thymidine analog, which is promising for sensitizing human tumors. |
Last Update：2024-04-09 20:49:11
