ISOSAKURANETIN
Isosakuranetin
CAS: 480-43-3
Molecular Formula: C16H14O5
ISOSAKURANETIN - Names and Identifiers
| Name | Isosakuranetin |
| Synonyms | ISOSAKURANETIN Isosakuranetin ISOSAKURANETIN(P) ISOSAKURANETIN WITH HPLC 5,7-DIHYDROXY-4'-METHOXYFLAVANONE (2S)-5,7-Dihydroxy-4'-methoxyflavanone 5,7-DIHYDROXY-4''-METHOXYFLAVANONE hplc (S)-2,3-dihydro-5,7-dihydroxy-2-(4-methoxyphenyl)-4-benzopyrone (S)-2,3-Dihydro-2-(4-methoxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one |
| CAS | 480-43-3 |
| EINECS | 207-551-8 |
ISOSAKURANETIN - Physico-chemical Properties
| Molecular Formula | C16H14O5 |
| Molar Mass | 286.28 |
| Density | 1.370±0.06 g/cm3(Predicted) |
| Melting Point | 193-194°C |
| Boling Point | 539.2±50.0 °C(Predicted) |
| Specific Rotation(α) | -19.7 (EtOH) |
| Solubility | Soluble in chloroform, methanol, acetone, ethyl acetate, DMSO. |
| Appearance | Powder |
| pKa | 7.50±0.40(Predicted) |
| Storage Condition | 2-8℃ |
| MDL | MFCD00017313 |
| Physical and Chemical Properties | Yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the flying grass, Rosaceae cherry blossom Prunus serrulata. |
| In vitro study | Isosakuranetin stimulates melanin accumulation in a dose-dependent manner. In addition, Isosakuranetin at 30 μM gradually increases the expression of Tyr, TRP1, and TRP2 after 48 and 72 h. The MTT assay shows that Isosakuranetin decreases the number of cells at concentrations greater than 45 μM. Further analysis of trypan blue staining demonstrates that Isosakuranetin does not affect the viability of B16 melanocytes, but shows that Isosakuranetin decreases their proliferation rate. The tyrosinase activity of B16 melanocytes treated with 15 and 30 μM Isosakuranetin for 72 h is significantly increased by 2- and 3.2-fold, respectively, in comparison with that of the control cells. |
| In vivo study | Isosakuranetin dose-dependently increases the paw-withdrawal threshold within the dose range of 1.5 to 6 mg/kg. Post hoc analysis reveals that Isosakuranetin increases the paw-withdrawal threshold and statistical significance is seen at times 30 and 40 min for the dose of 3 mg/kg and 30 to 60 min for the dose of 6 mg/kg. |
ISOSAKURANETIN - Risk and Safety
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| HS Code | 29329990 |
ISOSAKURANETIN - Reference
| Reference Show more | 1. [IF=5.396] Xing Yan Liu et al."Metabolic profile and underlying improved bio-activity of Fructus aurantii immaturus by human intestinal bacteria."Food Funct. 2017 Jun;8(6):2193-2201 2. [IF=3] Xing-Yan LIU et al."Identification of active compound combination contributing to anti-inflammatory activity of Xiao-Cheng-Qi Decoction via human intestinal bacterial metabolism."Chin J Nat Medicines. 2018 Jul;16:513 |
ISOSAKURANETIN - Reference Information
| Product description | ISO-Cherry Blossom kiosk is a kind of white needle Crystal (chloroform-methanol), soluble in chloroform, methanol, acetone, ethyl acetate, DMSO. The UV lamp showed green fluorescence at 365nm, the reaction of magnesium hydrochloride powder was positive, and the reaction of concentrated sulfuric acid-vanillin showed orange red. |
| biological activity | isosakouranetin is a flavanone flavonoid that can be found in the fruits of Citrus bergamia. |
| Use | for content determination/identification/pharmacological experiments. |
Last Update：2024-04-10 22:29:15
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Multiple SpecificationsSpot supply
Product Name: (S)-Isosakuranetin Visit Supplier Webpage Request for quotationCAS: 480-43-3
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Isosakuranetin Visit Supplier Webpage Request for quotationCAS: 480-43-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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