Iervin
Jervine
CAS: 469-59-0
Molecular Formula: C27H39NO3
Iervin - Names and Identifiers
| Name | Jervine |
| Synonyms | Iervin Jervine Jervine(11-Ketocyclopamine) 17,23-epoxy-3-hydroxy-,(3beta,23beta)-veratraman-11-on 17,23-epoxy-3-hydroxy-,(3-beta,23-beta)-veratraman-11-on 4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetra (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetraMethyl-,(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)- |
| CAS | 469-59-0 |
| EINECS | 207-417-9 |
Iervin - Physico-chemical Properties
| Molecular Formula | C27H39NO3 |
| Molar Mass | 425.6 |
| Density | 1.18±0.1 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 242- 244°C |
| Boling Point | 541.31°C (rough estimate) |
| Specific Rotation(α) | D20 -150° (ethanol) (Saito); D20 -167.6° (chloroform) (Poethke) |
| Solubility | Insuluble (4.7E-3 g/L) (25 °C) |
| Appearance | Powder |
| Color | White |
| Maximum wavelength(λmax) | ['250nm(lit.)'] |
| Merck | 14,5264 |
| pKa | 14.98±0.70(Predicted) |
| Storage Condition | −20°C |
| Stability | Store in Freezer at - 20°C |
| Refractive Index | 1.6400 (estimate) |
| MDL | MFCD01684066 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Veratrum. |
| In vitro study | Compared with the control group, chondrocytes exposed to 25 μg/ml jervine showed a significant decrease in cell number, while there was no change in cell morphology or the intensity of Alcian blue staining. |
| In vivo study | Embryos exposed to jervine produce craniofacial bone malformations similar to the phenotype of Shh mutant embryos. The lower jaws of these embryos are significantly reduced in size, usually resulting in the loss of incisor teeth. Treatment of pregnant mice with jervine causes their embryos to develop jaw defects with a phenotype similar to that of prx1. |
Iervin - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | WG9700000 |
| HS Code | 29349990 |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | LD50 i.v. in mice: 9.3 mg/kg (Krayer); LD50 s.c. in male mice: 29 mg/kg (Tanaka) |
Iervin - Reference Information
| biological activity | Jervine (11-ketocopiper) is an inhibitor of Hedgehog signaling pathway (IC50=500-700 nM), the shh signaling pathway is inhibited by interaction with smoothened. |
| Target | Value |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:21:28
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