Name | Lobeline |
Synonyms | Lobelin Lobeline Inflatine LOBELINE HCl, a-(P) L-lobeline free base (-)-α-[(2R,6S)-6-[(S)-β-hydroxyphenethyl]-1-methyl-2-piperidinyl]acetophenone |
CAS | 90-69-7 |
EINECS | 202-012-3 |
Molecular Formula | C22H27NO2 |
Molar Mass | 337.46 |
Density | 1.0909 (rough estimate) |
Melting Point | 130-131° |
Boling Point | 473.76°C (rough estimate) |
Specific Rotation(α) | D15 -43° (alc) |
Solubility | H2O: 25 mg/mL |
Appearance | Powder |
pKa | 14.34±0.20(Predicted) |
Storage Condition | 2-8℃ |
Refractive Index | 1.5614 (estimate) |
Hazard Symbols | T - Toxic |
Risk Codes | 23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. |
Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
UN IDs | 1544 |
Hazard Class | 6.1(b) |
Packing Group | III |
Reference Show more | 1. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 |
What is Lobeline | Lobeline, alias: Lobeline, expectorant,. It is an alkaloid extracted from the mountain, which is a central stimulant. This product selectively stimulates the chemoreceptors of the carotid body, and causes the excitement of the respiratory center, the vagus nerve center and the vascular motor center. For neonatal asphyxia, carbon monoxide caused by asphyxia, inhalation anesthetics and other central depressants (such as opioids, barbiturates) poisoning and Pneumonia, diphtheria and other infectious diseases caused by Respiratory Insufficiency. Adverse reactions and toxicity were mild. Safety range is large, not easy to cause convulsions. In the application of this product, should strictly control the dosage and medication interval time, and close observation of the body reaction. |
uses | for neonatal asphyxia, carbon monoxide-induced asphyxia, inhalation anesthetics and other central depressants (such as opioids, barbiturates) poisoning and Pneumonia, diphtheria and other infectious diseases caused by Respiratory Insufficiency. |
category | toxic substances |
toxicity grade | height |
Acute toxicity | subcutaneous-rat LDL0: 80 mg/kg; Intraperitoneal-mouse LD50: 43.5 mg/kg |
flammability hazard characteristics | the leaf of the mountain stalk contains the alkali of the mountain stalk, which is not allowed to be consumed by the tea; emission of toxic nitrogen oxides by thermal decomposition |
storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored separately from food raw materials |
fire extinguishing agent | water, carbon dioxide, foam, dry powder |