Iptacopanhydrochloride

Iptacopanhydrochloride - Names and Identifiers

Name	Iptacopan hydrochloride
Synonyms	EOS-61917 LNP023 hcl Iptacopan HCl Iptacopan(lnp023) LNP023 hydrochloride Iptacopanhydrochloride Iptacopan hydrochloride 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoicacidhydrochloride
CAS	1646321-63-2

Iptacopanhydrochloride - Physico-chemical Properties

Molecular Formula	C25H31ClN2O4
Molar Mass	458.97764
Solubility	DMSO : 250 mg/mL (544.69 mM; Need ultrasonic)H2O : 50 mg/mL (108.94 mM; ultrasonic and warming and heat to 60°C)
Storage Condition	-20℃

Iptacopanhydrochloride - Reference

Reference

1. Dimitrios C Mastellos, et al. Expanding Complement Therapeutics for the Treatment of Paroxysmal Nocturnal Hemoglobinuria. Semin Hematol. 2018 Jul;55(3):167-175.2. Anna Schubart, et al. Small-molecule Factor B Inhibitor for the Treatment of Complement-Mediated Diseases. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7926-7931.3. Nello Mainolfi, et al. Discovery of 4-((2 S,4 S)-4-Ethoxy-1-((5-methoxy-7-methyl-1 H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases. J Med Chem. 2020 Jun 11;63(11):5697-5722.

Iptacopanhydrochloride - Preparation solution concentration reference

	1mg	5mg	10mg
1 mM	2.179 ml	10.894 ml	21.787 ml
5 mM	0.436 ml	2.179 ml	4.357 ml
10 mM	0.218 ml	1.089 ml	2.179 ml
5 mM	0.044 ml	0.218 ml	0.436 ml

Last Update：2024-01-02 23:10:35

Iptacopanhydrochloride - Animal Experiment

C57BL/6 mice with KRN-induced arthritis.

Last Update：2023-08-16 21:32:38

Iptacopanhydrochloride - Note

LNP023 hydrochloride is a potent, orally active, highly selective factor B inhibitor. LNP023 binds directly, reversibly and with high affinity to factor B with a KD of 7.9 nM. LNP023 inhibits factor B with an IC50 value of 10 nM.

Last Update：2023-08-16 21:32:38

Suzhou Biosyntech Co., Ltd

Iptacopanhydrochloride

Iptacopan hydrochloride

CAS: 1646321-63-2

Molecular Formula: C25H31ClN2O4

Iptacopanhydrochloride - Names and Identifiers

Iptacopanhydrochloride - Physico-chemical Properties

Iptacopanhydrochloride - Reference

Iptacopanhydrochloride - Preparation solution concentration reference

Iptacopanhydrochloride - Animal Experiment

Iptacopanhydrochloride - Note

Supplier List

Iptacopanhydrochloride Request for Quotation

Iptacopan hydrochloride

CAS: 1646321-63-2

Molecular Formula: C25H31ClN2O4

Iptacopanhydrochloride - Names and Identifiers

Iptacopanhydrochloride - Physico-chemical Properties

Iptacopanhydrochloride - Reference

Iptacopanhydrochloride - Preparation solution concentration reference

Iptacopanhydrochloride - Animal Experiment

Iptacopanhydrochloride - Note

Supplier List

Iptacopanhydrochloride