Name | 5,7-dihydroxy-6-methoxy-3-(4-methoxyphenyl)-4H-chromen-4-one |
Synonyms | irisoidone Irisolidone irisolidone 4'-Methoxytectorigenin 4'-O-Methyltectorigenin 5,7-Dihydroxy-6,4'-dimethoxyisoflavon 5,7-dihydroxy-6-methoxy-3-(4-methoxyphenyl)-4H-chromen-4-one 5,7-Dihydroxy-6-methoxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one 4H-1-Benzopyran-4-one, 5,7-dihydroxy-6-methoxy-3-(4-methoxyphenyl)- 4H-1-benzopyran-4-one, 5,7-dihydroxy-6-methoxy-3-(4-methoxyphenyl)- |
CAS | 2345-17-7 |
InChI | InChI=1/C17H14O6/c1-21-10-5-3-9(4-6-10)11-8-23-13-7-12(18)17(22-2)16(20)14(13)15(11)19/h3-8,18,20H,1-2H3 |
Molecular Formula | C17H14O6 |
Molar Mass | 314.29 |
Density | 1.402±0.06 g/cm3(Predicted) |
Melting Point | 190-191 °C |
Boling Point | 565.5±50.0 °C(Predicted) |
Flash Point | 212.3°C |
Solubility | Soluble in chloroform, ethyl acetate, slightly soluble in petroleum ether, insoluble in water |
Vapor Presure | 2.15E-13mmHg at 25°C |
Appearance | Pale yellow needle crystal |
pKa | 6.48±0.20(Predicted) |
Storage Condition | 2-8℃ |
Refractive Index | 1.645 |
Physical and Chemical Properties | Light yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Pueraria flower. |
In vitro study | Irisolidone shows the high efficacy for Volume-regulated anion channels (VRAC) blockade with an IC 50 of 9.8 μM in HEK293 cells. Irisolidone can inhibit endothelial cell proliferation. |