Iron, (dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-))-
Heme
CAS: 14875-96-8
Molecular Formula: C34H31FeN4O4-
Iron, (dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-))- - Names and Identifiers
Iron, (dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-))- - Physico-chemical Properties
| Molecular Formula | C34H31FeN4O4- |
| Molar Mass | 615.49 |
| Melting Point | 180℃ |
| Boling Point | 1128.5℃ at 760 mmHg |
| Solubility | Soluble in alkali hydroxide solution, hot ethanol or ammonia, slightly soluble in hot pyridine, insoluble in water, ether and chloroform. |
| Appearance | Powder |
| Storage Condition | 2-8℃ |
| MDL | MFCD00011615 |
| Physical and Chemical Properties | Dark purple luster fine needle-like crystals or dark brown particles, powder. Slightly special smell. Very unstable and easy to oxidize. Insoluble in water. Used as an iron fortifier, its absorption rate is about 3 times higher than that of ordinary iron agents, and the iron content is 1.0% ~ 2.5%. |
| Use | Nutrition Fortifier, blood tonic and food additive for Iron |
Iron, (dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-))- - Reference
| Reference Show more | 1. [IF=4.098] Qingying Guo et al."Spectroscopic and cytotoxicity studies on the combined interaction of (−)-epigallocatechin-3-gallate and anthracycline drugs with human serum albumin."Spectrochim Acta A. 2019 Nov;222:117213 2. [IF=3.361] Tianyi Gao et al."An electrochemical platform based on a hemin–rGO–cMWCNTs modified aptasensor for sensitive detection of kanamycin."Rsc Adv. 2021 Apr;11(26):15817-15824 |
Iron, (dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-))- - Nature
Open Data Verified Data
heme is a red blood element in the blood and muscle of higher animals. It exists in red blood cells and binds to proteins to form complex proteins, I .e., hemoglobin (Hb) or myoglobin (Mb). Hb is a carrier for the transport of 02 and a portion of CO2 and is a buffering substance that maintains the pH of the blood constant. Under certain conditions, the heme can be separated from the protein. Heme is formed by complexation of protoporphyrin with iron (II). Heme crystals are blue-black, insoluble in water, soluble in acidic acetone, alkaline aqueous solution, easy to form polymer in solution. Soluble in dilute ammonia, soluble in strong organic bases (such as trimethylamine). There is a resonance structure in its molecule and its properties are stable. hemin (hemin) is black green amorphous or long needle-like crystals, insoluble in water, soluble in acidic acetone and alkaline water. The molecular formula is C34 H32 CIFe(Ⅲ)N4 04 with a molecular weight of 651. 96. Mainly used for anti-anemia, anticancer drug raw materials.
Last Update：2024-01-02 23:10:35
Iron, (dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-))- - Preparation Method
Open Data Verified Data
There are many preparation methods of heme, and the following are some typical methods. 1. Add 60L of methanol and 1kg of diethylamine to the reaction tank, stir well, add 5kg of fresh bovine blood powder, stir at 45 ℃ to extract th, cool, filter, concentrate the filtrate to 5L, then add 10L of glacial acetic acid, 100g of strontium chloride was heated to remove residual methanol, and then the temperature was raised to 102-° C. For reaction th, cooled, and filtered to collect Hemin crystals. 85g of Hemin can be obtained by washing the Hemin crystal with glacial acetic acid, water, acetone and drying. 2. Add 60L methanol and 5kg spray-dried bovine red blood cells to the reaction tank, stir evenly, extract at 40 ℃ for 30min, cool, filter, concentrate the filtrate to 5L, add 10L glacial acetic acid and lOOg sodium chloride, further, 2L of water was added to dissolve, and the residual methanol was removed by heating and distillation, and then the temperature was raised to 100 ° C. For reaction th, cooled, and filtered to collect Hemin crystals. The Hemin crystals were washed with glacial acetic acid and water, and dried to obtain 65g Hemin. Take lOOkg Blood Powder, add 0.6 mol/L HCl solution lOOkg, stir hemolysis, spray dry to obtain acid blood powder 40kg. Take acidic hemoglobin 40kg, with 90% ethanol, 6% methanol and 4% water mixed solvent extraction 3 times, mixed solvent dosage 800L, 300L and 200L, respectively, combined supernatant, hemin can be obtained by distillation and concentration. 4.3L of glacial acetic acid saturated with solid sodium chloride was heated to 100-102 ° C., and 1L of pig blood with fibrin removed was slowly added under stirring. During the addition of pig blood, the liquid temperature was controlled at 90~103. After the addition of pig blood, the reaction was carried out at 100 C for 15 min. The reaction mixture was naturally cooled to about 60 ° C., and heme crystals were separated. The crystals were washed with 50% acetic acid, water, ethanol and ether, and dried to obtain 3g of heme.
Last Update：2022-01-01 11:16:40
Iron, (dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-))- - Introduction
Unstable. The maximum absorption wavelength (c = 10, sodium hydroxide solution) is 580nm(ε10 · 5). Median lethal dose (rat, vein) 4-32mg/g.
Last Update：2022-10-16 17:14:03
Iron, (dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-))- - Use
Open Data Verified Data
In the food industry, heme can replace nitrite and synthetic pigments in meat products. In the pharmaceutical industry, heme can be used as a raw material for the semi-synthesis of bilirubin, and can also be used for the preparation of anticancer drugs. It can also be made into a blood tonic.
Last Update：2022-01-01 11:16:40
Iron, (dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-))- - Introduction
Heme is an iron-containing molecule with specific properties and uses.
Nature:
Heme is a dark red compound with strong light absorption ability, which can absorb the maximum amount of light in the near infrared band, making it can be used as a fluorescent probe in the field of spectroscopy and biological imaging. Heme shows high stability and good solubility in solution, and has good optical properties.
Use:
Heme is widely used in biomedical research and clinical applications. It has important applications in drug delivery, biological labeling, fluorescence microscopy and molecular imaging. Heme can be modified as a carrier for targeted drug delivery, and can also be combined with proteins, nucleic acids and drugs as biomarkers for detecting and tracking molecular processes in organisms. In addition, Heme can also be used for the preparation of dye-sensitized solar cells and optoelectronic devices.
Preparation Method:
Heme is usually made from animal tissue by synthesis or extraction. In the synthesis method, the common method is to synthesize the porphyrin precursor compound, and then synthesize Heme by various reducing agents, such as sulfite or reduction of magnesium and iron powder. In animal tissue extraction, Heme can be extracted from blood, muscle and other tissues.
Safety Information:
Heme in accordance with the relevant provisions of international standards, under the right conditions of use generally will not cause harmful effects on the human body. However, when using Heme, it is necessary to note that operations such as perfusion and injection of its solution should be carried out under sterile conditions to avoid cross-infection or other adverse reactions. In addition, for the powder or solid form of Heme, care should also be taken to prevent accidental ingestion or contact with sensitive areas such as eyes and mouth to prevent unnecessary injury. During use, it should be operated in accordance with relevant safety operation procedures. If there is an accident, should be timely medical treatment.
Nature:
Heme is a dark red compound with strong light absorption ability, which can absorb the maximum amount of light in the near infrared band, making it can be used as a fluorescent probe in the field of spectroscopy and biological imaging. Heme shows high stability and good solubility in solution, and has good optical properties.
Use:
Heme is widely used in biomedical research and clinical applications. It has important applications in drug delivery, biological labeling, fluorescence microscopy and molecular imaging. Heme can be modified as a carrier for targeted drug delivery, and can also be combined with proteins, nucleic acids and drugs as biomarkers for detecting and tracking molecular processes in organisms. In addition, Heme can also be used for the preparation of dye-sensitized solar cells and optoelectronic devices.
Preparation Method:
Heme is usually made from animal tissue by synthesis or extraction. In the synthesis method, the common method is to synthesize the porphyrin precursor compound, and then synthesize Heme by various reducing agents, such as sulfite or reduction of magnesium and iron powder. In animal tissue extraction, Heme can be extracted from blood, muscle and other tissues.
Safety Information:
Heme in accordance with the relevant provisions of international standards, under the right conditions of use generally will not cause harmful effects on the human body. However, when using Heme, it is necessary to note that operations such as perfusion and injection of its solution should be carried out under sterile conditions to avoid cross-infection or other adverse reactions. In addition, for the powder or solid form of Heme, care should also be taken to prevent accidental ingestion or contact with sensitive areas such as eyes and mouth to prevent unnecessary injury. During use, it should be operated in accordance with relevant safety operation procedures. If there is an accident, should be timely medical treatment.
Last Update：2024-04-09 20:52:54
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View History
Iron, (dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-))-
3-Aminophthalicacidhydrochloridelhydrate
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Dexamethasone Ep Impurity C
氧化钌(IV)
N-乙酰基-DL-甲硫氨酸
N-(2,4-Dinitrophenyl)-p-toluidine
6,6'-Dimethyl-2,2'-dipyridyl