Isoliquiritigenin

Name	Isoliquiritigenin
Synonyms	gu17 Isoliquiritigenin Isqliquiritigenin ISOLIQUIRITIGENIN(P) ISOLIQUIRITIGENIN(RG) (E)-2',4,4'-Trihydroxychalcone ISOLIQUIRTEGENIN (2',4,4'-TRIHYDROXYCHAL (E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one, 4,2μ,4μ-Trihydroxychalcone
CAS	961-29-5
EINECS	607-884-2
InChI	InChI=1/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+
InChIKey	DXDRHHKMWQZJHT-FPYGCLRLSA-N

Molecular Formula	C15H12O4
Molar Mass	256.25
Density	1.384±0.06 g/cm3(Predicted)
Melting Point	206-210°C
Boling Point	504.0±42.0 °C(Predicted)
Solubility	Insoluble in water, soluble in less polar solvents, such as ether, chloroform.
Appearance	Yellow needle crystal
Color	yellow to orange
BRN	1914296
pKa	7.50±0.35(Predicted)
Storage Condition	2-8°C
Sensitive	Light Sensitive & Hygroscopic
MDL	MFCD00075907
Physical and Chemical Properties	Yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from licorice, Dianthus.
Use	Used as cosmetic additives, food additives, etc
In vitro study	Isoliquiritigenin may be effective in preventing diabetic complications by inhibiting rat lens aldose reductase with an IC50 of 320 nM and in preventing the accumulation of sorbitol in human erythrocytes with an IC50 of 2.0 μm. Isoliquiritigenin can be used as a whitening agent by inhibiting the activity of mono-phenol tyrosinase and diphenol tyrosinase with IC50 of 8.1 μm. In DU145 and LNCaP cell lines, Isoliquiritigenin induced cell cycle arrest and inhibited cell growth. In human gastric cancer MGC-803 cells, Isoliquiritigenin induces apoptosis by increasing intracellular free calcium ion concentration, and decreasing mitochondrial membrane potential (Deltapsi(m)).
In vivo study	LD50: Mice> 6 g/kg (Gavage)

Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37 - Wear suitable gloves.
WGK Germany	3
RTECS	FL7080000
HS Code	29145090

Plant Source:	licorice
biological activity	Isoliquiritigenin is a flavonoid secreted from the root system of glycyrhiza glabra, which can inhibit aldose reductase with IC50 of 320 nM. Has anti-tumor activity.
Target	Value
Aldose reductase (Cell-free assay)	320 nM
Use	a soluble activator of guanosine cyclase. Has anti-tumor activity. used as cosmetic additives, food additives, etc. isoliquitigenin (ISL, and antitumor activities as well as hepatoprotection against steato sis-induced oxidative stress. ISL indents quinone reduction -1, a phase II enzyme that deactivates radials and electrophysiology, with a concentration required to double activity (CD) value of 1.8 μm in murine pathema cells. soluble guanylate cyclase (guanylyl cyclase) activator. Anti-tumor activity

Last Update：2024-04-09 15:16:53

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