| Overview | 3-aminocrotonate isopropyl ester is an important chemical intermediate, especially the antihypertensive drugs Nimodipine and iradipine are important intermediates, and they are also important basic structural fragments in other chemical organic synthesis. The market demand for this intermediate is large, it has high industrial production value. |
| preparation | 500g of isopropyl acetoacetate is added to the reaction bottle, 401.0g of ammonium acetate is added, heated to 80 ℃ for reaction for 2h, the reaction of isopropyl acetoacetate is completely detected, saturated sodium bicarbonate solution is added and stirred for 20 minutes, liquid is separated, 500ml of water is added to the organic layer is added and stirred for 20 minutes, liquid is separated, and anhydrous sodium sulfate is added, the desiccant was removed by filtration to obtain 450.2g of product with 90.6% yield and 99.2% purity detected by HPLC. |
| chemical properties | liquid. Boiling point 80 ℃/133Pa, relative density 0.996, refractive index 1.4940, flash point 92 ℃. |
| use | nimodipine intermediate. |
| production method | prepared by reacting isopropyl acetoacetate with liquid ammonia. |
