Isopropylamine
Isopropylamine
CAS: 75-31-0
Molecular Formula: C3H9N
Isopropylamine - Names and Identifiers
| Name | Isopropylamine |
| Synonyms | MIPA MIPA nsc62775 iso-C3H7NH2 Isopropylamin Isopropylamine Isopropilamina 2-Aminopropane PropyldamineatomD monoisopropylamine iso-Propylamine gas iso-Propyl-d7-amine isopropylamine(2-aminopropane) isopropylamine(non-specificname) isopropylaminemethylnaphthalenesulfonate |
| CAS | 75-31-0 |
| EINECS | 200-860-9 |
| InChI | InChI=1/C3H9N/c1-3(2)4/h3H,4H2,1-2H3 |
Isopropylamine - Physico-chemical Properties
| Molecular Formula | C3H9N |
| Molar Mass | 59.11 |
| Density | 0.688 g/mL at 20 °C (lit.) |
| Melting Point | -101 °C |
| Boling Point | 32-35 °C33-34 °C (lit.) |
| Flash Point | −26°F |
| JECFA Number | 1581 |
| Water Solubility | soluble |
| Solubility | 1000g/l |
| Vapor Presure | 9.2 psi ( 20 °C) |
| Vapor Density | 2.04 (vs air) |
| Appearance | Crystalline Powder, Needles or Crystals |
| Color | APHA: ≤50 |
| Odor | Strong ammoniacal; pungent, irritating, typical amine. |
| Exposure Limit | TLV-TWA 5 ppm (～12 mg/m3) (ACGIH,MSHA, and OSHA); TLV-STEL 10 ppm(～24 mg/m3) (ACGIH); IDLH 4000 ppm(NIOSH). |
| Merck | 14,5209 |
| BRN | 605259 |
| pKa | 10.63(at 25℃) |
| PH | 13 (700g/l, H2O, 20℃) |
| Storage Condition | 2-8°C |
| Stability | Stable. Extremely flammable - note low boiling point and low flash point. Readily forms explosive mixtures with air. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, |
| Sensitive | Air Sensitive |
| Explosive Limit | 2-10.4%(V) |
| Refractive Index | n20/D 1.374(lit.) |
| Physical and Chemical Properties | a colorless, volatile liquid. Ammonia odor. Density 0.694. Melting Point -101 °c. The boiling point of 33~34 deg C. Refractive index 1.3770(15 degrees C). Soluble in water, strong alkaline. And dissolved in ethanol and ether. Flammable. Toxic. specific gravity (4 ℃):0.73 |
| Use | For the preparation of pesticides, drugs, vulcanization accelerator, also used as hard water treatment agent, detergent, etc. Colorless transparent liquid, no mechanical impurities. Mainly used in pesticides, pharmaceuticals, dyes and rubber processing. |
Isopropylamine - Risk and Safety
| Risk Codes | R12 - Extremely Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. R37 - Irritating to the respiratory system R35 - Causes severe burns R25 - Toxic if swallowed R20/21 - Harmful by inhalation and in contact with skin. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S29 - Do not empty into drains. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | UN 1221 3/PG 1 |
| WGK Germany | 1 |
| RTECS | NT8400000 |
| FLUKA BRAND F CODES | 34 |
| TSCA | Yes |
| HS Code | 2921 19 99 |
| Hazard Class | 3 |
| Packing Group | I |
| Toxicity | LD50 orally in rats: 820 mg/kg (Smyth) |
Isopropylamine - Nature
Open Data Verified Data
colorless transparent volatile liquid, flammable, ammonia odor, a strong alkaline reaction. With water, ethanol, ether, acetone, benzene and other miscible. The relative density was 0. 6886. Melting Point -95.2 °c. Boiling point 32.4 °c. Spontaneous ignition point 402. Refractive index 3742. Flash point (Open Cup)-37 °c.
Last Update：2024-01-02 23:10:35
Isopropylamine - Preparation Method
Open Data Verified Data
There are two main methods for industrial production of isopropylamine.
- acetone hydrogenation ammoniation of raw material acetone into a copper nickel clay as the catalyst reactor, under normal pressure and 150~220 ℃ temperature conditions, hydrogen and ammonia are introduced into the reaction, and the reaction product is purified by distillation to obtain isopropylamine, and diisopropylamine is also generated. The conversion rate of acetone was 98%, and the total yield of monoisopropylamine and diisopropylamine was more than 90%.
- isopropyl alcohol hydrogenation amination Isopropyl alcohol is reacted with ammonia and hydrogen at 195 ° C. And 1. 72MPA with a porous nickel-aluminum catalyst activated by barium hydroxide to produce mono-isopropylamine and diisopropylamine.
Last Update：2022-01-01 10:35:03
Isopropylamine - Use
Open Data Verified Data
This product is a solvent and raw material for organic synthesis. For the synthesis of pesticides (such as atrazine, atrazine, put out the net, kill grass and other herbicides), medicine (such as ganle, etc.), dye intermediates, rubber vulcanization accelerator, hard water treatment agent, detergent, detergent, detergent, depilatory agents, emulsifiers, surfactants and textile auxiliaries.
Last Update：2022-01-01 10:35:02
Isopropylamine - Safety
Open Data Verified Data
- This product is toxic, strong alkaline, concentrated solution can corrode skin and mucous membranes. Rat oral LD50 870mg/kg; Mouse oral LD50 820mg/kg. The maximum allowable concentration at the operating site is 5 × 10-6 (12mg/m3).
- This product is a Class I flammable liquid. Packed in an iron drum. The container should be sealed and stored in a cool and ventilated place. Storage should be with the oxidant Isolation. In case of fire, use carbon dioxide, sand, dry chemical powder or water mist.
Last Update：2022-01-01 10:35:03
Isopropylamine - Reference Information
| FEMA | 4238 | ISOPROPYLAMINE |
| olfactory Threshold | 0.025ppm |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Overview | isopropylamine is also known as 2-aminopropane. Colorless liquid. Ammonia odor. Molecular weight 59.11. The boiling point of 33~34 deg C. Relative density 0.694(15/4 C). Refractive index 1.3770(15 degrees C). Flash point -37 °c. Can be miscible with water, ethanol, ether. It is used as the raw material of pesticide, medicine, dye, rubber vulcanization accelerator, emulsifier, detergent and water treatment agent. It can be used for the production of pesticide Badan, chlorpromazine and indophenol hydrochloride, propranolol hydrochloride, indole Xinan and other drugs. |
| Application | isopropylamine can be used as a raw material of pesticide, medicine, dye, rubber vulcanization accelerator, emulsifier, detergent and water treatment agent. It can be used for the production of pesticide Badan, chlorpromazine and indophenol hydrochloride, propranolol hydrochloride, indole Xinan and other drugs. |
| preparation | method for production of isopropylamine:(1) acetone and recycled diisopropylamine, isopropyl alcohol and hydrogen and ammonia are heated to the reaction temperature of the first stage and fed to a fixed bed reactor equipped with a nickel-based catalyst for hydroamination, the molar ratio of acetone: Hydrogen: ammonia in the feed is 1: 2-4: 2-4, and the volumetric space velocity of liquid acetone is 0.1-0.5 h-1, the reactor is implemented as described in any one of claims 1 to 3;(2) the material from the reactor is cooled, gas-liquid separation is carried out, and the gas is compressed and recycled back to the reactor by the compressor, the liquid is sent to the deammoniation Tower, ammonia is separated from the top of the tower, and is sent to the reactor, and the material rich in isopropylamine is collected from the tower kettle;(3) the material from the deammoniation Tower kettle is introduced into the isopropylamine tower, the isopropylamine product is recovered from the top of the column by distillation in an isopropylamine column, and the material containing diisopropylamine, isopropanol and water is recovered from the column kettle;(4) the material from the isopropylamine column kettle is introduced into the dehydration column, the materials mainly composed of diisopropylamine and isopropanol are separated at the top of the column and recycled back to the reactor. |
| Use | for the production of pesticides, drugs, vulcanization accelerator, also used as hard water treatment agent, detergent, etc. Colorless transparent liquid, no mechanical impurities. Mainly used in pesticides, pharmaceuticals, dyes and rubber processing. used in the production of pesticides, pharmaceuticals, dye intermediates, rubber accelerators, hard water treatment agents and surfactants, isopropylamine (2-aminopropane), it is widely used in the pesticide industry, can be used for the synthesis of organophosphorus insecticides methyl isosalaphos, ethyl isosalaphos, phenphosphorus; Insect growth regulator Buprofezin; Fungicide isopurin, in addition, isopropylamine is also a raw material for medicines, dyes, rubber vulcanization accelerators, emulsifiers, detergents, water treatment agents, and the like. isopropylamine as solvent and raw material for organic synthesis. For the synthesis of pesticides, pharmaceuticals, dye intermediates, rubber vulcanization accelerators, emulsifiers, detergents, detergents, depilators, hard water treatment agents, surfactants and textile additives, can be used in the production of pesticide Batan and herbicide atrazine, A variety of herbicides, such as atractylox, extinguishing net, killing grass net, etc., are used in medicine for ganle, indophenol hydrochloride, propranolol hydrochloride, indole Xinan and other drugs. used in the production of herbicides, fungicides, pesticides, production of surfactants, detergents and emulsifiers intermediates, and pharmaceutical intermediates. |
| production method | There are two main industrial methods for producing isopropylamine: 1. The raw material acetone is sent into the reactor with copper-nickel-clay as catalyst by acetone hydrogenation amination method, and hydrogen and ammonia are introduced to react under the conditions of normal pressure and temperature of 150-220 ℃, the reaction product was purified by distillation to obtain isopropylamine, and diisopropylamine was also formed. The conversion rate of acetone was 98%, and the total yield of monoisopropylamine and diisopropylamine was more than 90%. Raw material consumption quota: acetone 1390kg/t, liquid ammonia 450kg/t. 2. Isopropyl alcohol hydrogenation amination method Isopropyl alcohol is reacted with ammonia and hydrogen at 195 ℃ and 1.72MPa through porous nickel-aluminum catalyst activated by barium hydroxide to produce mono-isopropylamine and di-isopropylamine. The total conversion rate of the reaction can reach 86%, and the yield of the product (based on isopropanol) can reach 96%, containing 37% of monoisopropylamine, 33% of diisopropylamine, 12% of isopropanol and 18% of water. There are two methods for preparing isopropylamine in industry: isopropanol method and acetone method. (1) The isopropanol method is obtained by reacting isopropanol, liquid ammonia and hydrogen in the gas phase in the presence of a catalyst. (CH3)2CHOH + NH4[H2]→ [catalyst](CH3)2CHNH2 + H2O (CH3)2CHOH +(CH3)2CHNH2[H2]→ [catalyst](CH3)2CH]2NH + H2O reaction temperature of 195 ℃, reaction pressure of 1.7MPa, using porous, the reaction was carried out on a nickel-aluminum catalyst activated by barium hydroxide. The product obtained by the reaction contains both monoisopropylamine and diisopropylamine. The ratio of monoisopropylamine and diisopropylamine in the product can be adjusted by changing the reaction conditions. (2) the acetone method is prepared by amination of acetone, ammonia and hydrogen in the presence of a catalyst. Ch3coc3 + NH3 + H2 →(CH3)2CHNH2 + h2och3och3 +(CH3)2CHNH2 + H2 →[(CH3)2CH]2NH + H2O reaction temperature 150 ℃, reaction pressure 4.5MPa, the general ratio is acetone: Ammonia: Hydrogen = 1: 2.5: 10(mol). Increasing the amount of ammonia is beneficial to the formation of isopropylamine, Increasing the amount of acetone is beneficial to the formation of diisopropylamine. |
| category | flammable liquid |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50: 820 mg/kg; Oral-mouse LD50: 2200 mg/kg |
| stimulation data | eye-rabbit 0.050 mg severe |
| explosive hazard characteristics | explosive when mixed with air |
| flammability hazard characteristics | in case of fire, high temperature, oxidant flammable; toxic NOx smoke from combustion |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; Stored separately from oxidants and acids |
| extinguishing agent | dry powder, dry sand, carbon dioxide, foam |
| Occupational Standard | TWA 12 mg/m3 |
| spontaneous combustion temperature | 755 ° F. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
| immediate life-and health-threatening concentration | 750 ppm |
Last Update：2024-04-09 21:04:16
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