Isourecumenol
Isourecumenol
CAS: 24063-71-6
Molecular Formula: C15H22O2
Isourecumenol - Names and Identifiers
Isourecumenol - Physico-chemical Properties
| Molecular Formula | C15H22O2 |
| Molar Mass | 234.33 |
| Density | 1.09±0.1 g/cm3(Predicted) |
| Melting Point | 142-143℃ |
| Boling Point | 351.0±42.0 °C(Predicted) |
| Specific Rotation(α) | +34 (c, 1.0 in CHCl3) |
| Solubility | Slightly soluble (1.2g/L) (25°C) |
| Appearance | Powder |
| pKa | 12.70±0.40(Predicted) |
| Storage Condition | 2-8℃ |
| In vitro study | Isocurcumenol (12.5-400 µg/mL, 24-48 h) dose-dependently inhibits cancer cells proliferation. isocurcumenol does not exhibit any significant toxicity on normal chicken embryo fibroblast cells and lymphocytes. |
Isourecumenol - Reference
| Reference Show more | 1. Yu Mengting, Tong Huang Jin, Mao Chunqin, Sudan, Yin Fangzhou, Fei Cheng Hao, Wang Meng, Ji De, Lu Jiulin. Quality identification of different Rhizoma curcumae decoction pieces based on color quantification and main component content [J]. Chinese Journal of Traditional Chinese Medicine, 2021,46(06):1393-1400. |
Isourecumenol - Reference Information
| attribute | curcumol has significant anti-inflammatory effect, can significantly inhibit the production of NO in macrophages caused by lipopolysaccharide stimulation. Curcumenol belongs to guaiacane sesquiterpene, is a five-membered ring and seven-membered ring mutual coupling structure, but because of its poor water solubility, soluble in ethyl acetate, chloroform and other small polar organic solvents, it affects the formation of its formulation and drug development. |
| function | isosorbide has the effect of removing qi and blood, eliminating accumulation and relieving pain, and is used for blood stasis, amenorrhea, abdominal distension, etc, is more commonly used in clinical blood circulation drugs. |
| Application | commonly used in clinical blood gas, heart pain, diet stagnation, abdominal pain, blood stagnation, menstrual closure, dysmenorrhea, traumatic injury. Rhizoma curcumae contains volatile oil, curcumin and other components, the volatile oil is different from its anti-tumor active ingredients, and isocurcumol is the main active ingredient of Curcuma zedoariae in reducing blood lipid, anti-oxidation and anti-inflammatory. |
| biological activity | isocrucumenol can be isolated from curcema zedoaria Rhizomes and is an inhibitor of ERα. Has anti-tumor activity. Its IC50 for DLA and KB cancer cells were 99.1 μg/mL and 178.2 μg/mL, respectively. |
| Use | for content determination/identification/pharmacological experiments. |
Last Update：2024-04-09 21:04:16
Supplier List
Spot supply
Product Name: Isourecumenol Visit Supplier Webpage Request for quotationCAS: 24063-71-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Isourecumenol Visit Supplier Webpage Request for quotationCAS: 24063-71-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History