JACS-1847-58-1
Sodium Houttuyfonate
CAS: 1847-58-1
Molecular Formula: C14H29NaO5S
JACS-1847-58-1 - Names and Identifiers
| Name | Sodium Houttuyfonate |
| Synonyms | SLSA
Sudexanox JACS-1847-58-1 Sodium Houttuyfonate Sodium new houttuyfonate Sodium lauryl sulfoacetate SODIUM NEW HOUTTUYFONATE Dodecyl sodium sulfoacetate SODIUMLAURYLSULPHOACETATE (Sodiosulfo)acetic acid lauryl ester 2-(Sodiosulfo)acetic acid dodecyl ester sodium 2-(dodecyloxy)-2-oxoethanesulfonate 2-Sulfoacetic acid dodecyl ester sodium salt Natrium-2-(dodecyloxy)-2-oxoethan-1-sulfonat 2-[(Sodiooxy)sulfonyl]acetic acid 1-lauryl ester sodium 2-(dodecyloxy)-2-oxoethane-1-sulphonate Dodecyloxycarbonylmethanesulfonic acid sodium salt Acetic acid, sulfo-, 1-dodecyl ester, sodium salt |
| CAS | 1847-58-1 |
| EINECS | 217-431-7 |
| InChI | InChI=1/C14H28O5S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-19-14(15)13-20(16,17)18;/h2-13H2,1H3,(H,16,17,18);/q;+1 |
JACS-1847-58-1 - Physico-chemical Properties
| Molecular Formula | C14H29NaO5S |
| Molar Mass | 332.43 |
| Melting Point | >142°C (dec.) |
| Solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| Appearance | Solid |
| Color | White to Off-White |
| Storage Condition | Inert atmosphere,Room Temperature |
| Stability | Hygroscopic |
| Use | Anti-bacterial and anti-inflammatory drugs for the treatment of Upper Respiratory Infections, chronic bronchitis, Pneumonia and other diseases |
JACS-1847-58-1 - Upstream Downstream Industry
| Raw Materials | 2-Undecanone |
JACS-1847-58-1 - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Background | from natural Houttuynia cordata Thunb, Houttuynia cordata Thunb, its chemical name is decanoyl acetaldehyde (decanoyl acetaldehyde), the pharmaceutical preparation, has been widely used in clinical. The new sodium houttuyfonate synthesized by chemical method in China, the chemical name is dodecylacetaldehyde sodium bisulfite, and the pharmacological action and curative effect of decanoyl acetaldehyde are basically similar. The drug has antibacterial, antiviral, enhance immune function, anti-inflammatory, diuretic, anti Leptospira role. |
| Introduction | sodium new houttuyfonate is an adduct of new houttuyfonate and sodium bisulfite, the addition increases its solubility, sodium new houttuyfonate solution in the state of preservation process, easy to precipitate, causing increased adverse reactions in the clinical application process, in addition, the new houttuyfonate sodium solution is sensitive to light, can cause deterioration of drugs. |
| Clinical application | It is widely used in respiratory system diseases, gynecological diseases, digestive system diseases, surgical diseases and ENT diseases. |
| field of application | sodium houttuyfonate is a chemical compound of an aldehyde component in the volatile oil of the whole plant of the saururus family. Sodium new houttuyfonate has obvious inhibitory effect on Pneumonia Diplococcus, Salmonella Typhi, Staphylococcus aureus, Escherichia coli and sporothrix. It can improve the immunity of the body, enhance the phagocytic function of the white blood cells of the patients, improve the level of the serum solution, and improve the non-specific immunity of the body. New houttuyfonate sodium injection is mainly used for Annex inflammation, pelvic inflammatory disease, chronic cervicitis and other gynecological inflammation, and for Upper Respiratory Infections, chronic bronchitis, Pneumonia, etc. |
| preparation method | (1) take 3500g coconut oil and place it in an enamel container, add 750g sodium hydroxide and 250g sulfuric acid, after saponification and acidification; In the vacuum fractionation unit, under the condition of 150 ℃, pressure of mmHg, vacuum fractionation to obtain twelve acid;(2) preparation of calcium salt 1800g of screened lime was mixed with 2500ml of water to form a paste. Another 500g of dodecanoic acid was heated in a 10,000 porcelain drum to completely dissolve the mixture, and 2500g of glacial acetic acid was mixed well and poured into lime paste, continuous stirring, that is, calcium salt, placed overnight (calcium salt);(3) mixed ketone preparation: The prepared calcium salt, into the cracking tank, direct fire heating cracking for 10 hours, Preparation of mixed ketone about 750ml;(4) preparation of tridecanone -2 (fractional distillation) take the mixed ketone 1000ml, pour into a round-bottom flask, add 2~3 glass beads, to prevent boiling of the waterfall, the fractionating device is connected, and then heated (the temperature is controlled at 150 ℃, the pressure is controlled at mmHg) and vacuum distillation is carried out to collect the fractions in this range and weigh them to obtain tridecanone-2;(5) preparation of sodium salt of dodecylacetaldehyde: take tridecan-2200 G, 750g of ethyl formate and 1000ml of anhydrous benzene, mix them in a 5000ml triangular flask, then take 125g of metal sodium, mince them, and put them into the mixture in several times, and fully shake, the triangle flask is externally cooled with ice water, and the reaction liquid is kept at 25 ° C. At room temperature, the liquid is placed, and the sodium salt of dodecylacetaldehyde is obtained;(6) Dodecylacetaldehyde sodium bisulfite addition the above reactants were extracted 4 times with water: 2000ml × 2,1000ml × 2, and the water extracts were combined 4 times. Another 750g nahso3 was dissolved in 1500ml water and mixed with 250ml glacial acetic acid, add the above water extract, immediately generate a large amount of white precipitate, stir evenly, place the liquid, filter, filter dry, place the liquid, the precipitate is poured into the porcelain bucket, after heating and boiling in a water bath with 50% ml of ethanol, the mixture was filtered, and the filtrate was heated and boiled in the water bath and left overnight for recrystallization, then washed with water, then washed with ether until White, dried, and dried at 80 ° C., that is sodium new houttuyfonate. |
| biological activity | Sodium lauryl sulfoacetate is a solid anionic surfactant of plant origin. Sodium lauryl sulfoacetate is an immune adjuvant that has an anti-immunosuppressive effect. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:05
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Raw Materials for JACS-1847-58-1