JACS-3475-39-6
1,1,3-tribromo acetone
CAS: 3475-39-6
Molecular Formula: C3H3Br3O
JACS-3475-39-6 - Names and Identifiers
| Name | 1,1,3-tribromo acetone |
| Synonyms | JACS-3475-39-6 1,1,3-TribromoAceton 1,1,3-Tribromoacetone 1,1,3-tribromoacetone 1,1,3-tribromo acetone 1,1,3-Tribromopropan-2-one 1,1,3-tribromopropan-2-one 2-Propanone,1,1,3-tribromo- TIANFU-CHEM--1,1,3-Tribromoacetone |
| CAS | 3475-39-6 |
| InChI | InChI=1/C3H3Br3O/c4-1-2(7)3(5)6/h3H,1H2 |
JACS-3475-39-6 - Physico-chemical Properties
| Molecular Formula | C3H3Br3O |
| Molar Mass | 294.77 |
| Density | 2.561±0.06 g/cm3(Predicted) |
| Melting Point | 28-29 °C |
| Boling Point | 114-116 °C(Press: 14 Torr) |
| Flash Point | 115.1°C |
| Vapor Presure | 0.00875mmHg at 25°C |
| Refractive Index | 1.595 |
| In vivo study | Methotrexate (Amethopterin) reduces thymus and spleen indices of mice. Methotrexate markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate exposure on indices of thymus and spleens in mice. Methotrexate (MTX) (2 mg/kg; i.p.; once in a week for 5 weeks) is effective in Freund's complete adjuvant-induced arthritis. The combination of Methotrexate (1 mg/kg; i.p.; once in a week for 5 weeks) and Curcumin (30 mg/kg and 100 mg/kg, thrice a week for 5 weeks; i.p.) shows a significant anti-arthritic action and protection from hematological toxicity. |
JACS-3475-39-6 - Reference Information
| biological activity | 1,2, 3-Tribromoacetone is an impurity of methotrexate (HY-14519). Methotrexate (Amethopterin) is an antimetabolic (antimetabolite) and antifolate (antifolate) agent that inhibits dihydrofolate reductase, thereby preventing the conversion of folate to tetrahydrofolate and inhibiting DNA synthesis. |
Last Update：2024-04-09 21:01:54
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