JNJ-38877605
JNJ-38877618
CAS: 943540-74-7
Molecular Formula: C20H12F2N6
JNJ-38877605 - Names and Identifiers
JNJ-38877605 - Physico-chemical Properties
| Molecular Formula | C20H12F2N6 |
| Molar Mass | 374.35 |
| Storage Condition | 2-8℃ |
| Use | JNJ-38877618 is a potent, highly selective, orally available (Met) kinase inhibitor with IC50 values of 2 and 3 nM for the wild type and mutant, respectively. |
| In vivo study | In vivo, OMO-1 can completely inhibit tumor growth in 3 tumor models: SNU5 MET amp gastric cancer model, u87-MG HGF autocrine glioblastoma model and Hs746T gastric cancer model containing MET gene with exon 14 skip deletion mutation. The combination of OMO-1 and other drugs is well tolerated and can improve and enhance the targeted therapeutic effect of EGFR. Although single administration of OMO-1 had no effect on NSCLC HCC827 EGFR, its administration in combination with Erlotinib delayed tumor recurrence. |
JNJ-38877605 - Introduction
JNJ-38877618 is a chemical compound whose chemical properties are as follows:
Nature:
JNJ-38877618 is an organic compound with a molecular formula of C22H28N4O3 and a relative molecular mass of 408.49g/mol. It has the appearance of a white solid with a certain solubility.
Use:
JNJ-38877618 is a compound in drug research, mainly used in the research and development of cancer treatment. It is thought to have anti-tumor activity, possibly by interfering with the growth and proliferation mechanisms of cancer cells.
Preparation Method:
I cannot provide the specific preparation method, because JNJ-38877618 is a patented compound and its preparation method may be confidential, it can only be prepared by a professional drug manufacturing company or laboratory.
Safety Information:
Because JNJ-38877618 is an experimental drug, there is currently no adequate research data on its safety and toxicity. However, when conducting laboratory research, strict laboratory practices must be observed to ensure its safe use. Before carrying out any experiments, the safety data sheets and operating instructions should be read carefully and ensure that the experiments are carried out under the protection of safety equipment. Any JNJ-38877618-related experiments or applications should be carried out by professionals and in accordance with relevant regulations and guidelines.
Nature:
JNJ-38877618 is an organic compound with a molecular formula of C22H28N4O3 and a relative molecular mass of 408.49g/mol. It has the appearance of a white solid with a certain solubility.
Use:
JNJ-38877618 is a compound in drug research, mainly used in the research and development of cancer treatment. It is thought to have anti-tumor activity, possibly by interfering with the growth and proliferation mechanisms of cancer cells.
Preparation Method:
I cannot provide the specific preparation method, because JNJ-38877618 is a patented compound and its preparation method may be confidential, it can only be prepared by a professional drug manufacturing company or laboratory.
Safety Information:
Because JNJ-38877618 is an experimental drug, there is currently no adequate research data on its safety and toxicity. However, when conducting laboratory research, strict laboratory practices must be observed to ensure its safe use. Before carrying out any experiments, the safety data sheets and operating instructions should be read carefully and ensure that the experiments are carried out under the protection of safety equipment. Any JNJ-38877618-related experiments or applications should be carried out by professionals and in accordance with relevant regulations and guidelines.
Last Update：2024-04-09 20:45:29
