JSH23

Name	4-Methyl-N1-(3-phenylpropyl)benzene-1,2-diamine
Synonyms	JSH23 JSH 23 JSH-23 NF-κB Activation Inhibitor II NF-ΚB ACTIVATION INHIBITOR II 4-Methyl-N1-(3-phenylpropyl)-1,2-benzenediamine 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE 4-Methyl-N1-(3-phenylpropyl)benzene-1,2-diamine 4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine 4-Methyl-N1-(3-phenylpropyl)-1,2-benzenediamine JSH 23 JSH 23 4-Methyl-N1-(3-phenylpropyl)-1,2-benzenediamine
CAS	749886-87-1

Molecular Formula	C16H20N2
Molar Mass	240.34
Density	1.086±0.06 g/cm3(Predicted)
Melting Point	104.4-105.0℃
Boling Point	418.7±40.0 °C(Predicted)
Solubility	DMSO: >10mg/mL
Appearance	solid
Color	off-white to gray-pink
pKa	5.99±0.11(Predicted)
Storage Condition	-20°C
In vitro study	JSH-23 inhibited LPS-induced NF-κB p65 nuclear transport without affecting the degradation of IκB Alpha. JSH-23 inhibited LPS-induced apoptotic chromatin concentration, but showed no significant toxic effect on RAW 100 cells at <264.7 μm. JSH-23 also reduced NO production and neuronal migration in LPS-activated culture medium from mouse cerebellar primary cultures. In addition, JSH-23 increased the cytotoxicity of cisplatin compounds in ovarian cancer cells with CI values ranging from 0.35 to 0.85.
In vivo study	In diabetic rats, JSH-23(3 mg/kg) significantly reversed nerve conduction and improved neural blood flow deficits by reducing neuroinflammation and enhancing antioxidant defense.

Risk Codes	R22 - Harmful if swallowed R41 - Risk of serious damage to eyes R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets.
UN IDs	UN 3077 9 / PGIII
WGK Germany	3

Last Update：2024-01-02 23:10:35

biological activity	JSH-23 inhibits the transcriptional activity of NF-κB, IC50 is 7.1 μM.
in vitro study	JSH-23 inhibit LPS-induced NF-κB p65 nuclear transport without affecting IκBα degradation. JSH-23 inhibited LPS-induced apoptotic chromatin concentration, but did not show significant toxic effect on RAW 264.7 cells at <100 μM. JSH-23 also reduced LPS-activated NO production and neuronal migration in culture medium from mouse cerebellum primary culture. In addition, CI values ranged from 0.35 to 0.85 JSH-23 increasing the cytotoxicity of cisplatin compounds in ovarian cancer cells.
in vivo study	in diabetic rats, JSH-23(3 mg/kg) significantly reverses nerve conduction and improves nerve blood flow deficiency by reducing nerve inflammation and improving antioxidant defense.
target	NF-κB 7.1 μ m (IC 50 , in RAW 264.7 cells)

Last Update：2024-04-09 20:48:19

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JSH23

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