JTZ-951(Enarodustat) - Names and Identifiers
JTZ-951(Enarodustat) - Physico-chemical Properties
Molecular Formula | C17H16N4O4
|
Molar Mass | 340.33 |
Density | 1.44±0.1 g/cm3(Predicted) |
pKa | 0.58±0.53(Predicted) |
Storage Condition | -20℃ |
Use | Enarodustat is an effective, orally available factor prolyl hydroxylase inhibitor, EC50 of 0.22 μM. Enarodustat has the potential to be used in the study of renal anemia. |
JTZ-951(Enarodustat) - Preparation solution concentration reference
| 1mg | 5mg | 10mg |
---|
1 mM | 2.938 ml | 14.692 ml | 29.383 ml |
5 mM | 0.588 ml | 2.938 ml | 5.877 ml |
10 mM | 0.294 ml | 1.469 ml | 2.938 ml |
5 mM | 0.059 ml | 0.294 ml | 0.588 ml |
Last Update:2024-01-02 23:10:35
JTZ-951(Enarodustat) - Reference Information
biological activity | Enarodustat (JTZ-951) is a potent, the IC50 value for PHD2 was 0.22 μm and the EC50 value for EPO release from Hep3B cells was 5.7 μm. Enarodustat has the potential to treat renal anemia. |
Target | Value |
PHD2
(Cell-free assay)
| 0.22 μM |
EPO release from Hep3B cells
(Cell-based assay)
| 5.7 μM(EC50) |
Last Update:2024-04-09 15:16:57